Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma
No Thumbnail Available
Identifiers
Date
2021-12-01
Authors
Santisteban-Espejo, Antonio
Perez-Requena, Jose
Atienza-Cuevas, Lidia
Moran-Sanchez, Julia
del Carmen Fernandez-Valle, Maria
Bernal-Florindo, Irene
Romero-Garcia, Raquel
Garcia-Rojo, Marcial
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Mdpi
Metrics
Export
Abstract
The prognostic impact of the presence of Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) is controversial. Previous studies reported heterogeneous results, rendering difficult the clinical validation of EBV as a prognostic biomarker in this lymphoma. The objective of this study was to evaluate the survival impact of the expression of EBV Latent-Membrane Protein 1 (EBV-LMP1) in tumoral Hodgkin-Reed-Sternberg (HRS) cells of primary diagnostic samples of cHL. Formalin-Fixed Paraffin-Embedded (FFPE) lymph node samples from 88 patients with cHL were analyzed. Patients were treated with the standard first-line chemotherapy (CT) with Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) followed by radiotherapy. The Kaplan-Meier method and the Cox proportional hazards model were used for carrying out the survival analysis. In order to investigate whether the influence of EBV was age-dependent, analyses were performed both for patients of all ages and for age-stratified subgroups. In bivariate analysis, the expression of EBV was associated with older age (p = 0.011), mixed cellularity subtype cHL (p
Description
MeSH Terms
DeCS Terms
CIE Terms
Keywords
B-cell lymphomas, classical Hodgkin lymphoma, Epstein-Barr virus, Latent-Membrane Protein 1, risk-adjusted therapy, Age-defined subgroups, Reed-sternberg cells, B-cells, Presenting features, Disease, Impact, Ebv, Infection, Lmp1, Membrane-protein-1