Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA)
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Item Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress.(MDPI, 2021-09-14) Alonso-Piñeiro, Jose Angel; Gonzalez-Rovira, Almudena; Sánchez-Gomar, Ismael; Moreno, Juan Antonio; Durán-Ruiz, Ma Carmen; Institute of Health Carlos III; Spanish Biomedical Research Center in Cardiovascular Diseases; Spanish Ministry of Science and Innovation; Spanish Society of Nephrology; Consejería de Salud y Familias-FEDER; Programa Operativo de Andalucia-FEDERAtherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties.Item The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis.(MDPI, 2020-01-15) Martín-Valero, Rocio; Jimenez-Cebrian, Ana Maria; Moral-Munoz, Jose A; de-la-Casa-Almeida, Maria; Rodriguez-Huguet, Manuel; Casuso-Holgado, Maria JesusBackground: Respiratory muscle dysfunction is an important health problem with high morbidity and mortality and associated costs in patients with bronchiectasis (BC). The aim of this study was to analyse the effects of therapeutic respiratory muscle training (RMT) interventions on improving sputum clearance, ventilator function, muscle strength and functional capacity in BC. Methods: Systematic review and meta-analysis were conducted following PRISMA guidelines. Two independent investigators searched using several electronic databases. The methodological quality of nine studies was assessed using the PEDro scale. Study selection/eligibility criteria: The following were included: randomised controlled trials, randomised crossover trials and pilot studies of patients with BC that used the intervention as RMT (inspiratory/expiratory) and evaluations of respiratory muscle strength (maximal expiratory pressure/maximal inspiratory pressure). This systematic review was registered in PROSPERO (CRD42017075101). Nine studies were included, five of which obtained an A recommendation grade, three with B, and one with C. Study quality was poor to good (mean PEDro Score of 6.375 out of 10). Studies had small sample sizes (8-98). Results show improvements on PImax in favour of therapeutic respiratory muscle training intervention (MD = 6.08; 95% CI = 1.38, 10.77; p < 0.01; I2 = 92%). However, high heterogeneity was identified on meta-analysis.Item Criterion-Related Validity of Field-Based Fitness Tests in Adults: A Systematic Review.(MDPI, 2021-08-23) Castro-Piñero, Jose; Marin-Jimenez, Nuria; Fernandez-Santos, Jorge R; Martin-Acosta, Fatima; Segura-Jimenez, Victor; Izquierdo-Gomez, Rocio; Ruiz, Jonatan R; Cuenca-Garcia, Magdalena; Ministry of Economy, Industry and Competitiveness; Regional Government of Andalusia and University of CadizWe comprehensively assessed the criterion-related validity of existing field-based fitness tests used to indicate adult health (19-64 years, with no known pathologies). The medical electronic databases MEDLINE (via PubMed) and Web of Science (all databases) were screened for studies published up to July 2020. Each original study's methodological quality was classified as high, low and very low, according to the number of participants, the description of the study population, statistical analysis and systematic reviews which were appraised via the AMSTAR rating scale. Three evidence levels were constructed (strong, moderate and limited evidence) according to the number of studies and the consistency of the findings. We identified 101 original studies (50 of high quality) and five systematic reviews examining the criterion-related validity of field-based fitness tests in adults. Strong evidence indicated that the 20 m shuttle run, 1.5-mile, 12 min run/walk, YMCA step, 2 km walk and 6 min walk test are valid for estimating cardiorespiratory fitness; the handgrip strength test is valid for assessing hand maximal isometric strength; and the Biering-Sørensen test to evaluate the endurance strength of hip and back muscles; however, the sit-and reach test, and its different versions, and the toe-to-touch test are not valid for assessing hamstring and lower back flexibility. We found moderate evidence supporting that the 20 m square shuttle run test is a valid test for estimating cardiorespiratory fitness. Other field-based fitness tests presented limited evidence, mainly due to few studies. We developed an evidence-based proposal of the most valid field-based fitness tests in healthy adults aged 19-64 years old.Item The Impact of Scholastic Factors on Physical Activity Levels during the COVID-19 Lockdown: A Prospective Study on Adolescents from Bosnia and Herzegovina.(MDPI, 2021-10-01) Sekulic, Damir; Ostojic, Daria; Decelis, Andrew; Castro-Piñero, José; Jezdimirovic, Tatjana; Drid, Patrik; Ostojic, Ljerka; Gilic, Barbara; GALENO Research GroupScholastic factors (academic achievement) are hypothesized to be important determinants of health-related behaviors in adolescents, but there is a lack of knowledge on their influence on physical activity levels (PAL), especially considering the COVID-19 pandemic and the imposed lockdown. This study aimed to investigate the associations between scholastic factors and PAL before and during the pandemic lockdown. The participants were adolescents form Bosnia and Herzegovina (n = 525, 46% females), who were observed prospectively at the baseline (before the pandemic lockdown) and during the lockdown in 2020 (follow-up). The scholastic factors (grade point average, behavioral grade, school absences, unexcused absences) were evidenced at the baseline (predictors). The outcome (PAL) was evaluated using the Physical Activity Questionnaire for Adolescents at the baseline and the follow-up. Gender, age, parental/familial conflict, and sport participation were observed as confounders. No significant influence of the predictors on PAL were evidenced at the baseline or at the follow-up. The scholastic variables were significantly associated with the changes of PAL which occurred due to pandemic lockdown, with a lower risk for negative changes in PAL among adolescents who were better in school (OR = 0.56, 95%CI: 0.34-0.81, and OR = 0.66, 95%CI: 0.34-0.97, for the grade point average and behavioral grade, respectively). Students who do well in school are probably more aware of the health benefits of proper PAL, and therefore are devoted to the maintenance of their PAL even during the home-confinement of lockdown. Public health authorities should focus more on helping adolescents to understand the importance and benefits of proper PAL throughout the school system.Item Communication Styles and Attention Performance in Primary School Children(Mdpi, 2021-12-09) de la Torre, Gabriel G.; Ramallo, Miguel A.; Gonzalez-Torre, Sara; Mora Prat, Alvaro; Rueda-Marroquin, Andrea; Sallago-Marcos, Amanda; Toro-Barrios, Zoraida; Garcia, Manuel A.; [de la Torre, Gabriel G.] Univ Cadiz, Neuropsychol & Expt Psychol Lab, Campus Rio San Pedro, Cadiz 11510, Spain; [Ramallo, Miguel A.] Univ Cadiz, Neuropsychol & Expt Psychol Lab, Campus Rio San Pedro, Cadiz 11510, Spain; [Gonzalez-Torre, Sara] Univ Cadiz, Neuropsychol & Expt Psychol Lab, Campus Rio San Pedro, Cadiz 11510, Spain; [Garcia, Manuel A.] Univ Cadiz, Neuropsychol & Expt Psychol Lab, Campus Rio San Pedro, Cadiz 11510, Spain; [de la Torre, Gabriel G.] Biomed Res & Innovat Inst Cadiz INiBICA, Cadiz 11006, Spain; [Ramallo, Miguel A.] Biomed Res & Innovat Inst Cadiz INiBICA, Cadiz 11006, Spain; [Gonzalez-Torre, Sara] Biomed Res & Innovat Inst Cadiz INiBICA, Cadiz 11006, Spain; [Mora Prat, Alvaro] Univ Hosp Doctor Peset, Valencia 46017, Spain; [Rueda-Marroquin, Andrea] Univ Cadiz, Dept Psychol, Cadiz 11510, Spain; [Sallago-Marcos, Amanda] European Univ Valencia, Valencia 46010, Spain; [Toro-Barrios, Zoraida] Univ Huelva, Huelva 21007, Spain; [Garcia, Manuel A.] Univ Res Inst Sustainable Social Dev INDESS, Avda Univ,4 Campus Jerez, Cadiz 11405, SpainCommunication styles are the three communication patterns that result from merging the verbal elements of communication, the non-verbal elements and the paraverbal elements. The objective of this study was to test what effect different communication styles have on attention performance in primary school children. We administered the assertive behavior scale for children (CABS), the symbol digit modalities test (SDMT) and the d2 attention test to a sample of 77 participants of primary school. A statistically significant and proportional correlation was found between the assertive communication style and the total number of correct answers of the SDMT. We also found positive correlations between the assertive communication style and d2 attention test performance. Children with an assertive communication style have better attention performance than children with passive or aggressive communication styles.Item Trajectories of alcohol consumption during life and the risk of developing breast cancer.(Nature, 2021-09-06) Donat-Vargas, Carolina; Guerrero-Zotano, Ángel; Casas, Ana; Baena-Cañada, José Manuel; Lope, Virginia; Antolín, Silvia; Garcia-Saénz, José Ángel; Bermejo, Begoña; Muñoz, Montserrat; Ramos, Manuel; de Juan, Ana; Jara Sánchez, Carlos; Sánchez-Rovira, Pedro; Antón, Antonio; Brunet, Joan; Gavilá, Joaquín; Salvador, Javier; Arriola Arellano, Esperanza; Bezares, Susana; Fernández de Larrea-Baz, Nerea; Pérez-Gómez, Beatriz; Martín, Miguel; Pollán, Marina; Fundación Científica Asociación Española Contra el Cancer; Sociedad Española de Oncología Médica; Scholarship ‘Contrato de atracción de talento’ from Community of Madrid; Fundación Cerveza y Salud 2005; Federación de Asociaciones de Mujeres con Cáncer de Mama; GEICAM Spanish Breast Cancer Research GroupWhether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.Item Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma(Mdpi, 2021-12-15) Santisteban-Espejo, Antonio; Perez-Requena, Jose; Atienza-Cuevas, Lidia; Moran-Sanchez, Julia; del Carmen Fernandez-Valle, Maria; Bernal-Florindo, Irene; Romero-Garcia, Raquel; Garcia-Rojo, Marcial; [Santisteban-Espejo, Antonio] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain; [Perez-Requena, Jose] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain; [Atienza-Cuevas, Lidia] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain; [Garcia-Rojo, Marcial] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain; [Santisteban-Espejo, Antonio] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain; [Bernal-Florindo, Irene] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain; [Romero-Garcia, Raquel] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain; [Garcia-Rojo, Marcial] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain; [Santisteban-Espejo, Antonio] Univ Cadiz, Dept Med, Fac Med, Cadiz 11003, Spain; [Moran-Sanchez, Julia] Univ Cadiz, Dept Med, Fac Med, Cadiz 11003, Spain; [Moran-Sanchez, Julia] Puerta del Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz 11009, Spain; [del Carmen Fernandez-Valle, Maria] Puerta del Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz 11009, Spain; Andalusia Health System and with the EU FEDER ITI Grant for Cadiz Province; Postdoctoral grant from the Andalusia Health System; EU FEDER ITI Grant for Cadiz ProvinceThe prognostic impact of the presence of Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) is controversial. Previous studies reported heterogeneous results, rendering difficult the clinical validation of EBV as a prognostic biomarker in this lymphoma. The objective of this study was to evaluate the survival impact of the expression of EBV Latent-Membrane Protein 1 (EBV-LMP1) in tumoral Hodgkin-Reed-Sternberg (HRS) cells of primary diagnostic samples of cHL. Formalin-Fixed Paraffin-Embedded (FFPE) lymph node samples from 88 patients with cHL were analyzed. Patients were treated with the standard first-line chemotherapy (CT) with Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) followed by radiotherapy. The Kaplan-Meier method and the Cox proportional hazards model were used for carrying out the survival analysis. In order to investigate whether the influence of EBV was age-dependent, analyses were performed both for patients of all ages and for age-stratified subgroups. In bivariate analysis, the expression of EBV was associated with older age (p = 0.011), mixed cellularity subtype cHL (p < 0.001) and high risk International Prognostic Score (IPS) (p = 0.023). Overall survival (OS) and progression-free survival (PFS) were associated with the presence of bulky disease (p = 0.009) and advanced disease at diagnosis (p = 0.016). EBV-positive cases did not present a significantly lower OS and PFS in comparison with EBV-negative cases, for all ages and when stratifying for age. When adjusted for covariates, absence of bulky disease at diagnosis (HR: 0.102, 95% CI: 0.02-0.48, p = 0.004) and limited disease stages (I-II) (HR: 0.074, 95% CI: 0.01-0.47, p = 0.006) were associated with a significant better OS. For PFS, limited-disease stages also retained prognostic impact in the multivariate Cox regression (HR: 0.145, 95% CI: 0.04-0.57, p = 0.006). These results are of importance as the early identification of prognostic biomarkers in cHL is critical for guiding and personalizing therapeutic decisions. The prognostic role of EBV in cHL could be modulated by the type of CT protocol employed and interact with the rest of presenting features.Item Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering(Jmir publications, inc, 2021-11-26) Santisteban-Espejo, Antonio; Angel Martin-Piedra, Miguel; Campos, Antonio; Moran-Sanchez, Julia; Cobo, Manuel J.; Pacheco-Serrano, Ana, I; Moral-Munoz, Jose A.; [Santisteban-Espejo, Antonio] Puerta Mar Univ Hosp, Dept Pathol, Cadiz, Spain; [Santisteban-Espejo, Antonio] Univ Cadiz, Inst Res & Innovat Biomed Sci Prov Cadiz INiBICA, Cadiz, Spain; [Moral-Munoz, Jose A.] Univ Cadiz, Inst Res & Innovat Biomed Sci Prov Cadiz INiBICA, Cadiz, Spain; [Angel Martin-Piedra, Miguel] Univ Granada, Dept Histol, Tissue Engn Grp, Granada, Spain; [Campos, Antonio] Univ Granada, Dept Histol, Tissue Engn Grp, Granada, Spain; [Moran-Sanchez, Julia] Univ Cadiz, Dept Med, Cadiz, Spain; [Moran-Sanchez, Julia] Puerta Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz, Spain; [Cobo, Manuel J.] Univ Cadiz, Dept Comp Sci & Engn, Cadiz, Spain; [Pacheco-Serrano, Ana, I] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz, Spain; [Moral-Munoz, Jose A.] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz, Spain; CTS-115 (Tissue Engineering Research Group, University of Granada) from Junta de Andalucia, Spain; Spanish State Research Agency; Andalusia Health System; European Union Fondo Europeo de Desarrollo Regional para la Inversion Territorial Integrada Grant for Cadiz ProvinceTissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-stage organs. Its development has taken place since the last decade of the 20th century, entailing a clinical revolution. TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. The objective of this study was to evaluate the online dimension of TE documents from 2012 to 2018 using metadata obtained from the Web of Science (WoS) and Altmetric and to develop a prediction equation for the impact of TE documents from altmetric scores. We analyzed 10,112 TE documents through descriptive and statistical methods. First, the TE temporal evolution was exposed for WoS and 15 online platforms (news, blogs, policy, Twitter, patents, peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, video, and Mendeley Readers). The 10 most cited TE original articles were ranked according to the normalized WoS citations and the normalized Altmetric Attention Score. Second, to better comprehend the TE online framework, correlation and factor analyses were performed based on the suitable results previously obtained for the Bartlett sphericity and Kaiser-Meyer-Olkin tests. Finally, the linear regression model was applied to elucidate the relation between academics and online media and to construct a prediction equation for TE from altmetrics data. TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers, and Altmetric Scores. However, WoS and Altmetric rankings for the most cited documents clearly differ. When compared, the best correlation results were obtained for Mendeley Readers and WoS (ρ=0.71). In addition, the factor analysis identified 6 factors that could explain the previously observed differences between academic institutions and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than 40% of TE WoS citations from Altmetric scores. Scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because the focus of TE research importantly differs when the academic institutions and online platforms are compared, basic and clinical research groups, academic institutions, and health politicians should make a coordinated effort toward the design and implementation of adequate strategies for information diffusion and population health education.Item Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis.(Neurology, 2021-08-31) Cruz-Gomez, Álvaro J; Forero, Lucía; Lozano-Soto, Elena; Cano-Cano, Fátima; Sanmartino, Florencia; Rashid-López, Raúl; Paz-Expósito, Jsé; Gómez Ramirez, Jaime D; Espinosa-Rosso, Raúl; González-Rosa, Javier J; European Regional Development Fund and the Spanish Ministry of Science, Innovation and Universities; Ministry of Economy and CompetitivenessTo determine the relative importance of global or regional MRI and blood markers of neurodegeneration and neuroaxonal injury in predicting cognitive performance for recently diagnosed patients with multiple sclerosis (MS). Thirty-five newly diagnosed patients with relapsing-remitting MS (RRMS) and 23 healthy controls (HCs) simultaneously completed a full clinical and neuropsychological assessment, structural brain MRI, and serum neurofilament light chain (sNfL) level test. Linear regression analyses were performed to determine which global or regional measures of gray matter (GM) atrophy and cortical thickness (CT), in combination with sNfL levels and clinical scores, are most strongly related to neuropsychological impairment. Compared with HCs, patients with MS showed bilateral thalamic GM atrophy (left, p = 0.033; right, p = 0.047) and diminished CT, particularly in the right superior and transverse temporal gyri (p = 0.045; p = 0.037). Regional atrophy failed to add predictive variance, whereas anxiety symptoms, sNfL, and global CT were the best predictors (R2 = 0.404; p < 0.001) of cognitive outcomes, with temporal thickness accounting for greater variance in cognitive deficits than global CT. Thalamic GM atrophy and thinning in temporal regions represent a distinctive MRI trait in the early stages of MS. Although sNfL levels alone do not clearly differentiate HCs and patients with RRMS, in combination with global and regional CT, sNfL levels can better explain the presence of underlying cognitive deficits. Hence, cortical thinning and sNfL increases can be considered 2 parallel neurodegenerative markers in the pathogenesis of progression in newly diagnosed patients with MS.Item Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review(Mdpi, 2021-11-19) Jimenez-Cortegana, Carlos; Iglesias, Pedro; Ribalta, Josep; Vilarino-Garcia, Teresa; Montanez, Laura; Arrieta, Francisco; Aguilar, Manuel; Duran, Santiago; Obaya, Juan C.; Becerra, Antonio; Pedro-Botet, Juan; Sanchez-Margalet, Victor; Cardiovasc Dis Working Grp; Spanish Soc Diabet SED; [Jimenez-Cortegana, Carlos] Univ Seville, Virgen Macarena Univ Hosp, Dept Med Biochem & Mol Biol & Immunol, Av Dr Fedriani 3, Seville 41009, Spain; [Vilarino-Garcia, Teresa] Univ Seville, Virgen Macarena Univ Hosp, Dept Med Biochem & Mol Biol & Immunol, Av Dr Fedriani 3, Seville 41009, Spain; [Sanchez-Margalet, Victor] Univ Seville, Virgen Macarena Univ Hosp, Dept Med Biochem & Mol Biol & Immunol, Av Dr Fedriani 3, Seville 41009, Spain; [Iglesias, Pedro] Puerta de Hierro Univ Hosp, Endocrinol & Nutr Serv, Madrid 28034, Spain; [Ribalta, Josep] Univ Rovira & Vigili, Dept Med & Cirurgia, CIBERDEM, IISPV, Tarragona 43007, Spain; [Montanez, Laura] Ramon Y Cajal Univ Hosp, Endocrinol & Nutr Serv, Madrid 28034, Spain; [Arrieta, Francisco] Ramon Y Cajal Univ Hosp, Endocrinol & Nutr Serv, Madrid 28034, Spain; [Aguilar, Manuel] Cadiz Univ UCA, Univ Hosp Puerta del Mar, Inst Invest & Innovac Ciencias Biomed Prov Cadiz, Endocrinol & Nutr Serv, Cadiz 11001, Spain; [Duran, Santiago] Endodiabesidad Clin Duran & Asociados, Seville 41009, Spain; [Obaya, Juan C.] CHOPERA Hlth Ctr, Alcobendas Primary Care, Madrid 28034, Spain; [Becerra, Antonio] Univ Alcala, Dept Nutr, Madrid 28034, Spain; [Pedro-Botet, Juan] Autonomous Univ Barcelona, Hosp del Mar, Lipids & Cardiovasc Risk Unit, Barcelona 08003, Spain; [Jimenez-Cortegana, Carlos] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 14853 USA; Junta de Andalucia PAIDI; Spanish Society of Diaabetes (SED); The Cardiovascular Disease Working Group Of The Spanish Society Of Diabetes SedCardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence of CVD is much higher in patients with type 2 diabetes mellitus (T2DM), who may benefit from lifestyle changes, which include adapted diets. In this review, we provide the role of different groups of nutrients in patients with T2DM and CVD, as well as dietary approaches that have been associated with better and worse outcomes in those patients. Many different diets and supplements have proved to be beneficial in T2DM and CVD, but further studies, guidelines, and dietary recommendations are particularly required for patients with both diseases.Item Evidence-based recommendations of the Andalusian Group for Nutrition Reflection and Investigation (GARIN) for the management of adult patients with short bowel syndrome(Aula Medica Ediciones, 2021-11-29) Vilchez-Lopez, Francisco J.; Larran-Escandon, Laura; Garcia-Almeida, Jose M.; Arraiza-Irigoyen, Carmen; Irles-Rocamora, Jose A.; Molina-Puerta, Maria J.; Molina-Soria, Juan B.; Pereira-Cunill, Jose L.; Rabat-Restrepo, Juana M.; Rebollo-Perez, Maria I.; Serrano-Aguayo, Maria P.; Tenorio-Jimenez, Carmen; Olveira, Gabriel; Garcia-Luna, Pedro P.; [Vilchez-Lopez, Francisco J.] Hosp Univ Puerta del Mar, Endocrinol & Nutr Clin Management Unit, Cadiz, Spain; [Larran-Escandon, Laura] Hosp Univ Puerta del Mar, Endocrinol & Nutr Clin Management Unit, Cadiz, Spain; [Vilchez-Lopez, Francisco J.] Inst Invest Biomed Cadiz INIBICA, Cadiz, Spain; [Larran-Escandon, Laura] Inst Invest Biomed Cadiz INIBICA, Cadiz, Spain; [Garcia-Almeida, Jose M.] Hosp Univ Virgen Victoria, Endocrinol & Nutr Clin Management Unit, Malaga, Spain; [Garcia-Almeida, Jose M.] Inst Invest Biomed Malaga IBIMA, Malaga, Spain; [Olveira, Gabriel] Inst Invest Biomed Malaga IBIMA, Malaga, Spain; [Arraiza-Irigoyen, Carmen] Complejo Hosp Jaen, Dept Endocrinol & Nutr, Jaen, Spain; [Irles Rocamora, Jose A.] Hosp Univ Valme, Endocrinol & Nutr Clin Management Unit, Seville, Spain; [Molina-Puerta, Maria J.] Hosp Univ Reina Sofia, Endocrinol & Nutr Clin Management Unit, Cordoba, Spain; [Molina-Puerta, Maria J.] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain; [Molina Soria, Juan B.] Hosp Gen Linares, Nutr & Dietet Unit, Jaen, Spain; [Pereira-Cunill, Jose L.] Hosp Univ Virgen Rocio, Endocrinol & Nutr Clin Management Unit, Seville, Spain; [Serrano-Aguayo, Maria P.] Hosp Univ Virgen Rocio, Endocrinol & Nutr Clin Management Unit, Seville, Spain; [Garcia-Luna, Pedro P.] Hosp Univ Virgen Rocio, Endocrinol & Nutr Clin Management Unit, Seville, Spain; [Pereira-Cunill, Jose L.] Inst Biomed Sevilla IBiS, Endocrine Dis Res Grp, Seville, Spain; [Serrano-Aguayo, Maria P.] Inst Biomed Sevilla IBiS, Endocrine Dis Res Grp, Seville, Spain; [Garcia-Luna, Pedro P.] Inst Biomed Sevilla IBiS, Endocrine Dis Res Grp, Seville, Spain; [Rabat-Restrepo, Juana M.] Hosp Univ Virgen Macarena, Dept Endocrinol & Nutr, Seville, Spain; [Rebollo-Perez, Maria I.] Hosp Juan Ramon Jimenez, Dept Endocrinol & Nutr, Huelva, Spain; [Tenorio-Jimenez, Carmen] Hosp Univ Virgen Nieves, Endocrinol & Nutr Clin Management Unit, Granada, Spain; [Olveira, Gabriel] Univ Malaga, Hosp Reg Univ Malaga, Endocrinol & Nutr Clin Management Unit, Malaga 29010, Spain; [Olveira, Gabriel] Inst Salud Carlos III, CIBERDEM CB07 08 0019, Madrid, Spain; [Garcia-Luna, Pedro P.] GARIN Grp, Seville, Spain; NESTLE HEALTHCAREIn order to develop evidence-based recommendations and expert consensus for the nutritional management of patients with short bowel syndrome (SBS), we conducted a systematic literature search using the PRISMA methodology plus a critical appraisal following the GRADE scale procedures. Pharmacological treatment with antisecretory drugs, antidiarrheal drugs, and somatostatin contributes to reducing intestinal losses. Nutritional support is based on parenteral nutrition; however, oral intake and/or enteral nutrition should be introduced as soon as possible. In the chronic phase, the diet should have as few restrictions as possible, and be adapted to the SBS type. Home parenteral nutrition (HPN) should be individualized. Single-lumen catheters are recommended and taurolidine should be used for locking the catheter. The HPN's lipid content must be greater than 1 g/kg per week but not exceed 1 g/kg per day, and omega-6 fatty acids (omega 6 FAs) should be reduced. Trace element vials with low doses of manganese should be used. Patients with chronic SBS who require long-term HPN/fluid therapy despite optimized treatment should be considered for teduglutide treatment. All patients require a multidisciplinary approach and specialized follow-up. These recommendations and suggestions regarding nutritional management in SBS patients have direct clinical applicability.Item Physical Activity Promotion Programmes in Childhood Cancer Patients and Their Impact on Fatigue and Pain: A Systematic Review(Mdpi, 2021-12-02) Malysse, Catherine; Romero-Galisteo, Rita Pilar; Merchan-Baeza, Jose Antonio; Duran-Millan, J. Ignacio; Gonzalez-Sanchez, Manuel; Galan-Mercant, Alejandro; [Malysse, Catherine] Univ Malaga, Fac Hlth Sci, Dept Physiotherapy, Avda Cervantes 2, Malaga 29071, Spain; [Romero-Galisteo, Rita Pilar] Univ Malaga, Fac Hlth Sci, Dept Physiotherapy, Avda Cervantes 2, Malaga 29071, Spain; [Duran-Millan, J. Ignacio] Univ Malaga, Fac Hlth Sci, Dept Physiotherapy, Avda Cervantes 2, Malaga 29071, Spain; [Gonzalez-Sanchez, Manuel] Univ Malaga, Fac Hlth Sci, Dept Physiotherapy, Avda Cervantes 2, Malaga 29071, Spain; [Romero-Galisteo, Rita Pilar] Inst Invest Biomed Malaga, IBIMA, Malaga 29010, Spain; [Duran-Millan, J. Ignacio] Inst Invest Biomed Malaga, IBIMA, Malaga 29010, Spain; [Gonzalez-Sanchez, Manuel] Inst Invest Biomed Malaga, IBIMA, Malaga 29010, Spain; [Merchan-Baeza, Jose Antonio] Cent Univ Catalonia UVIC UCC, Univ Vic, Res Grp Methodol Methods Models & Outcomes Hlth &, Ctr Hlth & Social Care Res CESS,Fac Hlth Sci & We, C Sagrada Familia 7, Vic 08500, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Fac Nursing & Physiotherapy, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11003, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Puerta Mar Univ Hosp Cadiz, Biomed Res & Innovat Inst Cadiz INiBICA, Res Unit, Cadiz 11002, Spain; Erasmus+ Strategic Partnership for Higher Education Program; Research Group on Methodology, Methods, Models and Outcomes of Health and Social Sciences; MOVE-IT Research GroupCancer is one of the main causes of death in children, however, the techniques and interventions applied allow the cure of 80% of diagnosed cases. The aim of this review was to determine the benefits of a health and physical activity promotion programme to reduce pain and fatigue symptoms in children and adolescents with cancer. The databases PubMed, Embase, Scopus, Cochrane, Web of Science and PEDro were searched between December 2020 and January 2021 to elaborate this review, using the keywords child, cancer, exercise, fatigue and pain. The review was preregistered in PROSPERO (ID CRD42021262183). Six studies, out of 937 identified at baseline, were finally included in the review: four randomised controlled trials and two quasi-experimental studies. The total sample size of all the included studies was of 474 participants with very different types of cancer and evolution, and outcome variables were pain, fatigue, physical activity level, self-efficacy and quality of life. A health and physical activity promotion programme seems to improve fatigue in paediatric cancer patients and survivors, but no significant results were found related to pain.Item Polyaniline Nanofibers-Embedded Gold Nanoparticles Obtained by Template-Free Procedure with Immobilization Prospects(Mdpi, 2021-12-18) Crespo-Rosa, Joaquin Rafael; Sierra-Padilla, Alfonso; Garcia-Guzman, Juan Jose; Lopez-Iglesias, David; Bellido-Milla, Dolores; Palacios-Santander, Jose Maria; Cubillana-Aguilera, Laura; [Crespo-Rosa, Joaquin Rafael] Univ Puerto Real, Dept Analyt Chem, Inst Res Electron Microscopy & Mat IMEYMAT, Fac Sci,Campus Excelencia Int Mar CEIMAR, Campus Univ Puerto Real, Cadiz 11510, Spain; [Sierra-Padilla, Alfonso] Univ Puerto Real, Dept Analyt Chem, Inst Res Electron Microscopy & Mat IMEYMAT, Fac Sci,Campus Excelencia Int Mar CEIMAR, Campus Univ Puerto Real, Cadiz 11510, Spain; [Lopez-Iglesias, David] Univ Puerto Real, Dept Analyt Chem, Inst Res Electron Microscopy & Mat IMEYMAT, Fac Sci,Campus Excelencia Int Mar CEIMAR, Campus Univ Puerto Real, Cadiz 11510, Spain; [Bellido-Milla, Dolores] Univ Puerto Real, Dept Analyt Chem, Inst Res Electron Microscopy & Mat IMEYMAT, Fac Sci,Campus Excelencia Int Mar CEIMAR, Campus Univ Puerto Real, Cadiz 11510, Spain; [Palacios-Santander, Jose Maria] Univ Puerto Real, Dept Analyt Chem, Inst Res Electron Microscopy & Mat IMEYMAT, Fac Sci,Campus Excelencia Int Mar CEIMAR, Campus Univ Puerto Real, Cadiz 11510, Spain; [Cubillana-Aguilera, Laura] Univ Puerto Real, Dept Analyt Chem, Inst Res Electron Microscopy & Mat IMEYMAT, Fac Sci,Campus Excelencia Int Mar CEIMAR, Campus Univ Puerto Real, Cadiz 11510, Spain; [Garcia-Guzman, Juan Jose] Univ Cadiz, Inst Invest & Innovac Biomed Cadiz INiBICA, Hosp Univ Puerta del Mar, Cadiz 11009, Spain; Programa de Fomento e Impulso de la Investigacion y de la Transferencia de la Universidad de Cadiz 2020-2021In this work, template-free nanostructured conducting polymers (nCPs)-embedded gold nanoparticles (AuNPs) from aniline, thiophene and 3,4-ethylenedioxythiophene have been prepared via a one-pot sonochemical method. The synthesis of the nanocomposite (nCPs-AuNPs) was achieved in a short period of time (5-10 min), by applying high-energy ultrasound to an aqueous mixture of a CP precursor monomer and KAuCl4, in the presence of LiClO4 as dopant. The synthesis process is simpler, greener and faster in comparison to other procedures reported in the literature. Remarkably, bulk quantities of doped polyaniline PANI-AuNPs nanofibers were obtained. Subsequently, they were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR), as well as by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). PANI-AuNPs nanofibers were also employed as immobilization matrix for a benchmark enzyme, glucose oxidase (GOX). Finally, glucose was determined in real samples of white and red wines by using the so-obtained GOX-PANI-AuNPs/Sonogel-Carbon biosensor, providing outstanding recoveries (99.54%). This work may offer important insights into the synthesis of nanostructured conducting polymers and also stimulates the exploration of the applications of these nanocomposites, especially in research fields such as (bio)sensors, catalysis and composite materials.Item Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity(Mdpi, 2021-11-27) Cuevas, Belen; Arroba, Ana I.; de los Reyes, Carolina; Gomez-Jaramillo, Laura; Gonzalez-Montelongo, M. Carmen; Zubia, Eva; [Cuevas, Belen] Univ Cadiz, Fac Ciencias Mar & Ambientales, Dept Quim Organ, Puerto Real 11510, Cadiz, Spain; [de los Reyes, Carolina] Univ Cadiz, Fac Ciencias Mar & Ambientales, Dept Quim Organ, Puerto Real 11510, Cadiz, Spain; [Zubia, Eva] Univ Cadiz, Fac Ciencias Mar & Ambientales, Dept Quim Organ, Puerto Real 11510, Cadiz, Spain; [Cuevas, Belen] Hosp Univ Puerta Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Unidad Invest, Avda Ana Viya 21, Cadiz 11009, Spain; [Arroba, Ana I.] Hosp Univ Puerta Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Unidad Invest, Avda Ana Viya 21, Cadiz 11009, Spain; [Gomez-Jaramillo, Laura] Hosp Univ Puerta Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Unidad Invest, Avda Ana Viya 21, Cadiz 11009, Spain; [Gonzalez-Montelongo, M. Carmen] Hosp Univ Puerta Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Unidad Invest, Avda Ana Viya 21, Cadiz 11009, Spain; [Arroba, Ana I.] Hosp Univ Puerta Mar, Dept Endocrinol & Nutr, Avda Ana Viya 21, Cadiz 11009, Spain; Junta de Andalucía, Spain (ITI-FEDER)Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids, whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids: rugukadiol A (1), rugukamurals A-C (2-4), and ruguloptones A-F (6-10). The structures of the new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2-10 belong to the secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In anti-inflammatory assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage cells RAW 264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2 and the pro-inflammatory cytokine Il1b in both immune cell lines.Item Effectiveness of Stretching in Post-Stroke Spasticity and Range of Motion: Systematic Review and Meta-Analysis(Mdpi, 2021-10-24) Gomez-Cuaresma, Laura; Lucena-Anton, David; Gonzalez-Medina, Gloria; Martin-Vega, Francisco Javier; Galan-Mercant, Alejandro; Luque-Moreno, Carlos; [Gomez-Cuaresma, Laura] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Lucena-Anton, David] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Gonzalez-Medina, Gloria] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Martin-Vega, Francisco Javier] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Luque-Moreno, Carlos] Univ Cadiz, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Lucena-Anton, David] Univ Cadiz, Dept Informat Engn, Intell SOK TIC Res Grp 256, Cadiz 11519, Spain; [Gonzalez-Medina, Gloria] Univ Cadiz, Univ Inst Res Social Sustainable Dev INDESS, Phys Therapy & Hlth FISA, Invest Grp CTS986, Cadiz 11009, Spain; [Galan-Mercant, Alejandro] Sci Univ Cadiz, Fac Educ, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11002, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Puerta Mar Univ Hosp, Biomed Res & Innovat Inst, Cadiz INiBICA Res Unit, Cadiz 11002, Spain; [Luque-Moreno, Carlos] Univ Seville, Fac Nursing Physiotherapy & Podiatry, Dept Physiotherapy, Seville 41009, Spain; Erasmus+ Strategic Partnership for Higher Education Program; Intell-SOK (TIC-256) Research Group; MOVE-IT Research Group; Investigation Group CTS-986Spasticity is one of the most frequent and disabling clinical manifestations of patients with stroke. In clinical practice, stretching is the most widely used physiotherapeutic intervention for this population. However, there is no solid evidence for its effectiveness. The aim of this study was to evaluate the effectiveness of different types of stretching in reducing post-stroke spasticity. Research was carried out until March 2021 in the following scientific databases: PubMed, CINAHL, Scopus, Cochrane Library, Web of Science, and PEDro. The PEDro scale and the Cochrane collaboration tool were used to assess the methodological quality and risk of bias of the studies. Eight articles were selected for qualitative analysis; six of them contributed information to the meta-analysis. No conclusive evidence was obtained on the effectiveness of stretching in terms of treating spasticity and range of motion in patients with stroke. Further research is necessary in order to determine the effectiveness of the use of stretching in this population, considering the different types of stretching (static and dynamic), the time of application, the measurement of the different components of spasticity, and the extrapolation of functional results.Item Effectiveness of Global Postural Re-Education in Chronic Non-Specific Low Back Pain: Systematic Review and Meta-Analysis(Mdpi, 2021-11-16) Gonzalez-Medina, Gloria; Perez-Cabezas, Veronica; Ruiz-Molinero, Carmen; Chamorro-Moriana, Gema; Jimenez-Rejano, Jose Jesus; Galan-Mercant, Alejandro; [Gonzalez-Medina, Gloria] Univ Cadiz, Fac Nursing & Physiotherapy, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Ruiz-Molinero, Carmen] Univ Cadiz, Fac Nursing & Physiotherapy, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Fac Nursing & Physiotherapy, Dept Nursing & Physiotherapy, Cadiz 11009, Spain; [Gonzalez-Medina, Gloria] Inst Res Social Sustainable Dev INDESS, Res Grp CTS 986 Phys Therapy & Hlth FISA, Cadiz 11009, Spain; [Ruiz-Molinero, Carmen] Inst Res Social Sustainable Dev INDESS, Res Grp CTS 986 Phys Therapy & Hlth FISA, Cadiz 11009, Spain; [Perez-Cabezas, Veronica] Puerta del Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA, Res Grp CTS1038 eMpOwering Hlth Phys Act Exercise, Res Unit, Cadiz 11009, Spain; [Galan-Mercant, Alejandro] Puerta del Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA, Res Grp CTS1038 eMpOwering Hlth Phys Act Exercise, Res Unit, Cadiz 11009, Spain; [Chamorro-Moriana, Gema] Univ Seville, Dept Physiotherapy, Seville 41009, Spain; [Jimenez-Rejano, Jose Jesus] Univ Seville, Dept Physiotherapy, Seville 41009, Spain; [Chamorro-Moriana, Gema] Univ Seville, Res Grp CTS305 Area Physiotherapy CTS305, Seville 41009, Spain; [Jimenez-Rejano, Jose Jesus] Univ Seville, Res Grp CTS305 Area Physiotherapy CTS305, Seville 41009, Spain; Erasmus+ Strategic Partnership for Higher Education Programme; CTS-986 Physical Therapy and Health (FISA); [CTS1038] eMpOwering Health by Physical Activity, Exercise and Nutrition (MOVEIT); [CTS305] "Area of Physiotherapy CTS305"Background: The aim of this systematic review and meta-analysis was to evaluate the global postural re-education (GPR) program's effectiveness compared to other exercise programs in subjects with persistent chronic low back pain. Methods: A systematic review and meta-analysis were carried out using PRISMA2020. An electronic search of scientific databases was performed from their inception to January 2021. Randomized controlled trials that analyzed pain and patient-reported outcomes were included in this review. Four meta-analyses were performed. The outcomes analyzed were disability due to back pain and pain. The risk of bias and quality of evidence were evaluated. The final search was conducted in March. Results: Seven trials were included, totaling 334 patients. The results showed improvement in pain measured by Visual Analogue Scale (VAS) (Standardised Mean Difference (SMD) = -0.69; 95% Confidence Interval (CI), -1.01 to -0.37; p < 0.0001), Numerical Pain Scale (NRS) (SMD = -0.40; 95% CI, -0.87 to 0.06); p = 0.022), VAS + NRS (SMD = -1.32; 95% CI, -1.87 to -0.77; p < 0.0001) and function (Roland Morris Disability Questionnaire (RMDQ)) (SMD = -0.55; 95% CI, -0.83 to -0.27; p < 0.0001) after GPR treatment. Conclusion: This meta-analysis provides reliable evidence that GPR may be an effective method for treating LBP by decreasing pain and improving function, with strong evidence.Item Elderly Population with COVID-19 and the Accuracy of Clinical Scales and D-Dimer for Pulmonary Embolism: The OCTA-COVID Study(Mdpi, 2021-11-20) Quezada-Feijoo, Maribel; Ramos, Monica; Lozano-Montoya, Isabel; Sarro, Monica; Muinos, Veronica Cabo; Ayala, Rocio; Gomez-Pavon, Francisco J.; Toro, Rocio; [Quezada-Feijoo, Maribel] Hosp Cent Cruz Roja, Cardiol Dept, C Reina Victoria 24, Madrid 28003, Spain; [Ramos, Monica] Hosp Cent Cruz Roja, Cardiol Dept, C Reina Victoria 24, Madrid 28003, Spain; [Ayala, Rocio] Hosp Cent Cruz Roja, Cardiol Dept, C Reina Victoria 24, Madrid 28003, Spain; [Quezada-Feijoo, Maribel] Univ Alfonso X El Sabio, Fac Med, Avda De la Univ 1, Madrid 28691, Spain; [Ramos, Monica] Univ Alfonso X El Sabio, Fac Med, Avda De la Univ 1, Madrid 28691, Spain; [Lozano-Montoya, Isabel] Univ Alfonso X El Sabio, Fac Med, Avda De la Univ 1, Madrid 28691, Spain; [Ayala, Rocio] Univ Alfonso X El Sabio, Fac Med, Avda De la Univ 1, Madrid 28691, Spain; [Gomez-Pavon, Francisco J.] Univ Alfonso X El Sabio, Fac Med, Avda De la Univ 1, Madrid 28691, Spain; [Lozano-Montoya, Isabel] Hosp Cent Cruz Roja, Geriatr Dept, C Reina Victoria 24, Madrid 28003, Spain; [Gomez-Pavon, Francisco J.] Hosp Cent Cruz Roja, Geriatr Dept, C Reina Victoria 24, Madrid 28003, Spain; [Sarro, Monica] Hosp Cent La Cruz Roja, Radiol Dept, C Reina Victoria 24, Madrid 28003, Spain; [Muinos, Veronica Cabo] Hosp Cent Cruz Roja, Biochem Lab, C Reina Victoria 24, Madrid 28003, Spain; [Toro, Rocio] Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA, Res Unit, Av Ana Viya 21, Cadiz 11009, Spain; [Toro, Rocio] Univ Cadiz, Sch Med, Med Dept, Edificio Andres Segovia 30 Floor,C Dr Maranon S-N, Cadiz 21001, Spain; Universidad Alfonso X el Sabio; Fundacion Publica Andaluza Progreso y Salud para la Financiacion; European Regional Development Fund (ERDF); Spanish Society of Cardiology (SEC) for Basic ResearchBackground: Elderly COVID-19 patients have a high risk of pulmonary embolism (PE), but factors that predict PE are unknown in this population. This study assessed the Wells and revised Geneva scoring systems as predictors of PE and their relationships with D-dimer (DD) in this population. Methods: This was a longitudinal, observational study that included patients ≥75 years old with COVID-19 and suspected PE. The performances of the Wells score, revised Geneva score and DD levels were assessed. The combinations of the DD level and the clinical scales were evaluated using positive rules for higher specificity. Results: Among 305 patients included in the OCTA-COVID study cohort, 50 had suspected PE based on computed tomography pulmonary arteriography (CTPA), and the prevalence was 5.6%. The frequencies of PE in the low-, intermediate- and high-probability categories were 5.9%, 88.2% and 5.9% for the Geneva model and 35.3%, 58.8% and 5.9% for the Wells model, respectively. The DD median was higher in the PE group (4.33 mg/L; interquartile range (IQR) 2.40-7.17) than in the no PE group (1.39 mg/L; IQR 1.01-2.75) (p < 0.001). The area under the curve (AUC) for DD was 0.789 (0.652-0.927). After changing the cutoff point for DD to 4.33 mg/L, the specificity increased from 42.5% to 93.9%. Conclusions: The cutoff point DD > 4.33 mg/L has an increased specificity, which can discriminate false positives. The addition of the DD and the clinical probability scales increases the specificity and negative predictive value, which helps to avoid unnecessary invasive tests in this population.Item Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review(Mdpi, 2021-11-30) Leiva-Valderrama, Jose Manuel; Montes-de-Oca-Garcia, Adrian; Opazo-Diaz, Edgardo; Ponce-Gonzalez, Jesus G.; Molina-Torres, Guadalupe; Velazquez-Diaz, Daniel; Galan-Mercant, Alejandro; [Leiva-Valderrama, Jose Manuel] Univ Cadiz, Puerta Mar Univ Hosp, Fac Nursing & Physiotherapy, Cadiz 11009, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Puerta Mar Univ Hosp, Fac Nursing & Physiotherapy, Cadiz 11009, Spain; [Montes-de-Oca-Garcia, Adrian] Univ Cadiz, Fac Educ Sci, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11519, Spain; [Opazo-Diaz, Edgardo] Univ Cadiz, Fac Educ Sci, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11519, Spain; [Ponce-Gonzalez, Jesus G.] Univ Cadiz, Fac Educ Sci, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11519, Spain; [Velazquez-Diaz, Daniel] Univ Cadiz, Fac Educ Sci, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11519, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Fac Educ Sci, Dept Phys Educ, MOVE IT Res Grp, Cadiz 11519, Spain; [Montes-de-Oca-Garcia, Adrian] Univ Cadiz, Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA Res Unit, Cadiz 11009, Spain; [Opazo-Diaz, Edgardo] Univ Cadiz, Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA Res Unit, Cadiz 11009, Spain; [Ponce-Gonzalez, Jesus G.] Univ Cadiz, Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA Res Unit, Cadiz 11009, Spain; [Velazquez-Diaz, Daniel] Univ Cadiz, Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA Res Unit, Cadiz 11009, Spain; [Galan-Mercant, Alejandro] Univ Cadiz, Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA Res Unit, Cadiz 11009, Spain; [Opazo-Diaz, Edgardo] Univ Chile, Fac Med, Dept Phys Therapy, Santiago 8380453, Chile; [Molina-Torres, Guadalupe] Univ Almeria, Fac Hlth Sci, Dept Nursing Physiotherapy & Med, Almeria 04120, Spain; Erasmus+ Strategic Partnership for Higher Education Program (Key Action 203); MOVE-IT Research GroupBackground: Due to the prevalence and incidence worldwide of type 2 diabetes, and the significant role physical activity plays in these patients, a systematic review has been conducted to find out the effects that high-intensity interval training has on inflammatory biomarkers in subjects with type 2 diabetes. This project aims to determine the effect this training modality has on inflammatory biomarkers, in addition to observing its effects on the values of body composition and determining if this is a more effective, less effective or equally effective alternative to standard aerobic or resistance training. Methods: A search was conducted in the months of November and December 2020 on different databases: Pubmed, WoS and PEDro. A protocol for this systematic review was registered in PROSPERO (Registration number: CRD42021281186). The studies selected met the previously defined inclusion criteria, and the methodological quality of the papers used was evaluated according to the Downs and Black Checklist. Results: Out of 46 studies found, seven were included. The most relevant data concerning the characteristics of the clinical trials and HIIT characteristics, the values of body composition and the biomarkers under study were extracted from each study. Moreover, the results obtained from the different studies were described. Conclusions: HIIT could have an effect on inflammatory biomarkers. There is likely to be a relationship between changes in inflammatory profile and fat loss. A controlled diet may be a good complement to reduce the inflammatory profile. Further studies are required to determine whether HIIT is a better, worse or an equivalent alternative to medium-intensity aerobic exercise to improve the inflammatory profile.Item Prevalence of Migraine in General Spanish Population Factors Related and Use of Health Resources(Mdpi, 2021-10-23) Salazar, Alejandro; Berrocal, Laura; Failde, Inmaculada; [Salazar, Alejandro] Univ Cadiz, Observ Pain, Cadiz 11009, Spain; [Failde, Inmaculada] Univ Cadiz, Observ Pain, Cadiz 11009, Spain; [Salazar, Alejandro] Univ Cadiz, Res Unit, Biomed Res & Innovat Inst Cadiz INiBICA, Puerta del Mar Univ Hosp, Cadiz 11009, Spain; [Failde, Inmaculada] Univ Cadiz, Res Unit, Biomed Res & Innovat Inst Cadiz INiBICA, Puerta del Mar Univ Hosp, Cadiz 11009, Spain; [Salazar, Alejandro] Univ Cadiz, Dept Stat & Operat Res, Puerto Real 11510, Spain; [Berrocal, Laura] Univ Cadiz, Prevent Med & Publ Hlth Area, Cadiz 11009, Spain; [Failde, Inmaculada] Univ Cadiz, Prevent Med & Publ Hlth Area, Cadiz 11009, SpainMigraine is a common neurological disorder considered the second most disabling condition worldwide. Its prevalence ranges from 2.6% to 21.7% in population studies. This study aimed to know the prevalence of diagnosed and undiagnosed migraine in the general Spanish adult population, their health care use, and factors related. A descriptive cross-sectional study was undertaken with 23,089 individuals > 15 years from the 2017 Spanish National Health Survey. Three groups were defined: people diagnosed with migraine (DM), people reporting undiagnosed migraine (UM) and people without migraine. Sociodemographic, clinical and use of health resources data were collected. The scales Duke Social Support Index (DSSI) and General Health Questionnaire (GHQ-12) were used. Prevalence of DM and UM were determined with 95% confidence intervals. To determine the factors associated with DM and UM, a multinomial logistic regression model was used. The prevalence of DM was 8.6% (95%CI: 8.2-9), and UM, 0.9% (95%CI: 0.8-1). People with DM more frequently visited healthcare professionals (47.8%), required more supplementary tests (86.8), had a higher percentage of hospitalization (11.3%), and used emergency services (45.1%). Women had nearly three times the risk of DM and UM. Worse mental health was a risk factor for UM (OR = 1.20) and DM (OR = 1.18). The greater the work stress, the greater the risk of DM (OR = 1.12). An adequate monitoring and management of migraine in people with these characteristics could contribute to improving their quality of life and reducing costs in the system.Item Potential Diagnostic Value of the Differential Expression of Histone H3 Variants between Low- and High-Grade Gliomas(Mdpi, 2021-10-20) Hervas-Corpion, Irati; Gallardo-Orihuela, Andrea; Catalina-Fernandez, Inmaculada; Iglesias-Lozano, Irene; Soto-Torres, Olga; Geribaldi-Doldan, Noelia; Dominguez-Garcia, Samuel; Luna-Garcia, Nuria; Romero-Garcia, Raquel; Mora-Lopez, Francisco; Iriarte-Gahete, Marianela; Morales, Jorge C.; Campos-Caro, Antonio; Castro, Carmen; Gil-Salu, Jose L.; Valor, Luis M.; [Hervas-Corpion, Irati] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Gallardo-Orihuela, Andrea] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Catalina-Fernandez, Inmaculada] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Iglesias-Lozano, Irene] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Soto-Torres, Olga] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Geribaldi-Doldan, Noelia] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Dominguez-Garcia, Samuel] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Luna-Garcia, Nuria] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Romero-Garcia, Raquel] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Mora-Lopez, Francisco] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Iriarte-Gahete, Marianela] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Morales, Jorge C.] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Campos-Caro, Antonio] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Castro, Carmen] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Gil-Salu, Jose L.] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Valor, Luis M.] Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain; [Hervas-Corpion, Irati] Hosp Univ Puerta Mar, Unidad Invest, Av Ana de Viya 21, Cadiz 11009, Spain; [Gallardo-Orihuela, Andrea] Hosp Univ Puerta Mar, Unidad Invest, Av Ana de Viya 21, Cadiz 11009, Spain; [Romero-Garcia, Raquel] Hosp Univ Puerta Mar, Unidad Invest, Av Ana de Viya 21, Cadiz 11009, Spain; [Morales, Jorge C.] Hosp Univ Puerta Mar, Unidad Invest, Av Ana de Viya 21, Cadiz 11009, Spain; [Campos-Caro, Antonio] Hosp Univ Puerta Mar, Unidad Invest, Av Ana de Viya 21, Cadiz 11009, Spain; [Valor, Luis M.] Hosp Univ Puerta Mar, Unidad Invest, Av Ana de Viya 21, Cadiz 11009, Spain; [Catalina-Fernandez, Inmaculada] Hosp Univ Puerta Mar, Unidad Gest Clin Anat Patol, Av Ana de Viya 21, Cadiz 11009, Spain; [Soto-Torres, Olga] Hosp Univ Puerta Mar, Unidad Gest Clin Anat Patol, Av Ana de Viya 21, Cadiz 11009, Spain; [Luna-Garcia, Nuria] Hosp Univ Puerta Mar, Unidad Gest Clin Anat Patol, Av Ana de Viya 21, Cadiz 11009, Spain; [Iglesias-Lozano, Irene] Hosp Univ Puerta Mar, Unidad Gest Clin Neurocirugia, Av Ana de Viya 21, Cadiz 11009, Spain; [Gil-Salu, Jose L.] Hosp Univ Puerta Mar, Unidad Gest Clin Neurocirugia, Av Ana de Viya 21, Cadiz 11009, Spain; [Geribaldi-Doldan, Noelia] Univ Cadiz, Fac Med, Area Fisiol, Plaza Fragela, Cadiz 11003, Spain; [Dominguez-Garcia, Samuel] Univ Cadiz, Fac Med, Area Fisiol, Plaza Fragela, Cadiz 11003, Spain; [Castro, Carmen] Univ Cadiz, Fac Med, Area Fisiol, Plaza Fragela, Cadiz 11003, Spain; [Geribaldi-Doldan, Noelia] Univ Cadiz, Fac Med, Dept Anat & Embriol Humanas, Plaza Fragela, Cadiz 11003, Spain; [Mora-Lopez, Francisco] Hosp Univ Puerta Mar, Serv Inmunol, Av Ana de Viya 21, Cadiz 11009, Spain; [Iriarte-Gahete, Marianela] Hosp Univ Puerta Mar, Serv Inmunol, Av Ana de Viya 21, Cadiz 11009, Spain; [Campos-Caro, Antonio] Univ Cadiz, Fac Ciencias Mar & Ambientales, Dept Biomed Biotecnol & Salud Publ, Area Genet, Cadiz 11510, Spain; [Valor, Luis M.] Inst Invest Sanitaria & Biomed Alicante ISABIAL, Alicante 03010, Spain; [Valor, Luis M.] Hosp Gen Univ Alicante, Lab Apoyo Invest, Av Pintor Baeza 12, Alicante 03010, Spain; Programa Estatal de Generacion de Conocimiento y Fortalecimiento del Sistema Espanol de I+D+i; Instituto de Salud Carlos III; Fondo Europeo de Desarrollo Regional 2014-2020; Plan Propio INiBICA; Ministerio de Ciencia e Innovacion; Consejeria de Economia, Conocimiento, Empresas y Universidades convocatoria de proyectos I+D+i en el marco operativo FEDER-Andalucia; Miguel Servet I contract; Miguel Servet II contract; Rio Hortega contract by Instituto de Salud Carlos III; Fondo Social Europeo 2014-2020, Programa Estatal de Promocion del Talento y su empleabilidad en I+D+iIn the search of the key factors that differentiate the aggressive glioblastomas from lower-grade gliomas, we determined that the variants of the structural protein of the nucleosome histone H3 show different degrees of expression. In general, high expression of H3.1/H3.2 was associated with clinical features of glioblastomas whereas high expression of H3.3 was linked to molecular alterations found in low-grade gliomas. In fact, those glioblastomas showing low expression levels of H3.1/H3.2 are highly similar to low-grade gliomas, suggesting an association with glioma aggressiveness that deserves further investigation in large cohorts. Glioblastoma (GB) is the most aggressive form of glioma and is characterized by poor prognosis and high recurrence despite intensive clinical interventions. To retrieve the key factors underlying the high malignancy of GB with potential diagnosis utility, we combined the analysis of The Cancer Gene Atlas and the REMBRANDT datasets plus a molecular examination of our own collection of surgical tumor resections. We determined a net reduction in the levels of the non-canonical histone H3 variant H3.3 in GB compared to lower-grade astrocytomas and oligodendrogliomas with a concomitant increase in the levels of the canonical histone H3 variants H3.1/H3.2. This increase can be potentially useful in the clinical diagnosis of high-grade gliomas, as evidenced by an immunohistochemistry screening of our cohort and can be at least partially explained by the induction of multiple histone genes encoding these canonical forms. Moreover, GBs showing low bulk levels of the H3.1/H3.2 proteins were more transcriptionally similar to low-grade gliomas than GBs showing high levels of H3.1/H3.2. In conclusion, this study identifies an imbalanced ratio between the H3 variants associated with glioma malignancy and molecular patterns relevant to the biology of gliomas, and proposes the examination of the H3.3 and H3.1/H3.2 levels to further refine diagnosis of low- and high-grade gliomas in future studies.