%0 Journal Article
%A Santisteban-Espejo, Antonio
%A Perez-Requena, Jose
%A Atienza-Cuevas, Lidia
%A Moran-Sanchez, Julia
%A del Carmen Fernandez-Valle, Maria
%A Bernal-Florindo, Irene
%A Romero-Garcia, Raquel
%A Garcia-Rojo, Marcial
%T Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma
%D 2021
%U https://hdl.handle.net/10668/25268
%X The prognostic impact of the presence of Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) is controversial. Previous studies reported heterogeneous results, rendering difficult the clinical validation of EBV as a prognostic biomarker in this lymphoma. The objective of this study was to evaluate the survival impact of the expression of EBV Latent-Membrane Protein 1 (EBV-LMP1) in tumoral Hodgkin-Reed-Sternberg (HRS) cells of primary diagnostic samples of cHL. Formalin-Fixed Paraffin-Embedded (FFPE) lymph node samples from 88 patients with cHL were analyzed. Patients were treated with the standard first-line chemotherapy (CT) with Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) followed by radiotherapy. The Kaplan-Meier method and the Cox proportional hazards model were used for carrying out the survival analysis. In order to investigate whether the influence of EBV was age-dependent, analyses were performed both for patients of all ages and for age-stratified subgroups. In bivariate analysis, the expression of EBV was associated with older age (p = 0.011), mixed cellularity subtype cHL (p
%K B-cell lymphomas
%K classical Hodgkin lymphoma
%K Epstein-Barr virus
%K Latent-Membrane Protein 1
%K risk-adjusted therapy
%K Age-defined subgroups
%K Reed-sternberg cells
%K B-cells
%K Presenting features
%K Disease
%K Impact
%K Ebv
%K Infection
%K Lmp1
%K Membrane-protein-1
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