RT Journal Article
T1 Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma
A1 Santisteban-Espejo, Antonio
A1 Perez-Requena, Jose
A1 Atienza-Cuevas, Lidia
A1 Moran-Sanchez, Julia
A1 del Carmen Fernandez-Valle, Maria
A1 Bernal-Florindo, Irene
A1 Romero-Garcia, Raquel
A1 Garcia-Rojo, Marcial
K1 B-cell lymphomas
K1 classical Hodgkin lymphoma
K1 Epstein-Barr virus
K1 Latent-Membrane Protein 1
K1 risk-adjusted therapy
K1 Age-defined subgroups
K1 Reed-sternberg cells
K1 B-cells
K1 Presenting features
K1 Disease
K1 Impact
K1 Ebv
K1 Infection
K1 Lmp1
K1 Membrane-protein-1
AB The prognostic impact of the presence of Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) is controversial. Previous studies reported heterogeneous results, rendering difficult the clinical validation of EBV as a prognostic biomarker in this lymphoma. The objective of this study was to evaluate the survival impact of the expression of EBV Latent-Membrane Protein 1 (EBV-LMP1) in tumoral Hodgkin-Reed-Sternberg (HRS) cells of primary diagnostic samples of cHL. Formalin-Fixed Paraffin-Embedded (FFPE) lymph node samples from 88 patients with cHL were analyzed. Patients were treated with the standard first-line chemotherapy (CT) with Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) followed by radiotherapy. The Kaplan-Meier method and the Cox proportional hazards model were used for carrying out the survival analysis. In order to investigate whether the influence of EBV was age-dependent, analyses were performed both for patients of all ages and for age-stratified subgroups. In bivariate analysis, the expression of EBV was associated with older age (p = 0.011), mixed cellularity subtype cHL (p
PB Mdpi
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/25268
UL https://hdl.handle.net/10668/25268
LA en
DS RISalud
RD Apr 18, 2025