Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma
dc.contributor.author | Santisteban-Espejo, Antonio | |
dc.contributor.author | Perez-Requena, Jose | |
dc.contributor.author | Atienza-Cuevas, Lidia | |
dc.contributor.author | Moran-Sanchez, Julia | |
dc.contributor.author | del Carmen Fernandez-Valle, Maria | |
dc.contributor.author | Bernal-Florindo, Irene | |
dc.contributor.author | Romero-Garcia, Raquel | |
dc.contributor.author | Garcia-Rojo, Marcial | |
dc.contributor.authoraffiliation | [Santisteban-Espejo, Antonio] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Perez-Requena, Jose] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Atienza-Cuevas, Lidia] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Garcia-Rojo, Marcial] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Santisteban-Espejo, Antonio] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Bernal-Florindo, Irene] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Romero-Garcia, Raquel] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Garcia-Rojo, Marcial] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [Santisteban-Espejo, Antonio] Univ Cadiz, Dept Med, Fac Med, Cadiz 11003, Spain | |
dc.contributor.authoraffiliation | [Moran-Sanchez, Julia] Univ Cadiz, Dept Med, Fac Med, Cadiz 11003, Spain | |
dc.contributor.authoraffiliation | [Moran-Sanchez, Julia] Puerta del Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz 11009, Spain | |
dc.contributor.authoraffiliation | [del Carmen Fernandez-Valle, Maria] Puerta del Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz 11009, Spain | |
dc.contributor.funder | Andalusia Health System and with the EU FEDER ITI Grant for Cadiz Province | |
dc.contributor.funder | Postdoctoral grant from the Andalusia Health System | |
dc.contributor.funder | EU FEDER ITI Grant for Cadiz Province | |
dc.date.accessioned | 2025-01-07T13:07:38Z | |
dc.date.available | 2025-01-07T13:07:38Z | |
dc.date.issued | 2021-12-15 | |
dc.description.abstract | The prognostic impact of the presence of Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) is controversial. Previous studies reported heterogeneous results, rendering difficult the clinical validation of EBV as a prognostic biomarker in this lymphoma. The objective of this study was to evaluate the survival impact of the expression of EBV Latent-Membrane Protein 1 (EBV-LMP1) in tumoral Hodgkin-Reed-Sternberg (HRS) cells of primary diagnostic samples of cHL. Formalin-Fixed Paraffin-Embedded (FFPE) lymph node samples from 88 patients with cHL were analyzed. Patients were treated with the standard first-line chemotherapy (CT) with Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) followed by radiotherapy. The Kaplan-Meier method and the Cox proportional hazards model were used for carrying out the survival analysis. In order to investigate whether the influence of EBV was age-dependent, analyses were performed both for patients of all ages and for age-stratified subgroups. In bivariate analysis, the expression of EBV was associated with older age (p = 0.011), mixed cellularity subtype cHL (p < 0.001) and high risk International Prognostic Score (IPS) (p = 0.023). Overall survival (OS) and progression-free survival (PFS) were associated with the presence of bulky disease (p = 0.009) and advanced disease at diagnosis (p = 0.016). EBV-positive cases did not present a significantly lower OS and PFS in comparison with EBV-negative cases, for all ages and when stratifying for age. When adjusted for covariates, absence of bulky disease at diagnosis (HR: 0.102, 95% CI: 0.02-0.48, p = 0.004) and limited disease stages (I-II) (HR: 0.074, 95% CI: 0.01-0.47, p = 0.006) were associated with a significant better OS. For PFS, limited-disease stages also retained prognostic impact in the multivariate Cox regression (HR: 0.145, 95% CI: 0.04-0.57, p = 0.006). These results are of importance as the early identification of prognostic biomarkers in cHL is critical for guiding and personalizing therapeutic decisions. The prognostic role of EBV in cHL could be modulated by the type of CT protocol employed and interact with the rest of presenting features. | |
dc.description.sponsorship | This work has been supported by a postdoctoral grant (RH-0145-2020) from the Andalusia Health System and with the EU FEDER ITI Grant for Cadiz Province PI-0032-2017. | |
dc.description.version | Sí | |
dc.identifier.citation | Santisteban-Espejo A, Perez-Requena J, Atienza-Cuevas L, Moran-Sanchez J, del Carmen Fernandez-Valle M, Bernal-Florindo I, et al. Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma. Viruses. 2021;13(12):2523. Published 2021 Dec 15. | |
dc.identifier.doi | 10.3390/v13122523 | |
dc.identifier.essn | 1999-4915 | |
dc.identifier.issn | 1999-4915 | |
dc.identifier.pmc | PMC8706848 | |
dc.identifier.pmid | 34960792 | |
dc.identifier.unpaywallURL | https://www.mdpi.com/1999-4915/13/12/2523/pdf?version=1639711053 | |
dc.identifier.uri | https://hdl.handle.net/10668/25268 | |
dc.identifier.wosID | 737465700001 | |
dc.issue.number | 12 | |
dc.journal.title | Viruses-basel | |
dc.journal.titleabbreviation | Viruses-basel | |
dc.language.iso | en | |
dc.organization | SAS - Hospital Universitario Puerta del Mar | |
dc.organization | Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA) | |
dc.page.number | 14 | |
dc.provenance | Realizada la curación de contenido 20/05/2025 | |
dc.publisher | Mdpi | |
dc.relation.projectID | RH-0145-2020 | |
dc.relation.projectID | PI-0032-2017 | |
dc.relation.publisherversion | https://www.mdpi.com/1999-4915/13/12/2523 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | B-cell lymphomas | |
dc.subject | classical Hodgkin lymphoma | |
dc.subject | Epstein-Barr virus | |
dc.subject | Latent-Membrane Protein 1 | |
dc.subject | risk-adjusted therapy | |
dc.subject | Age-defined subgroups | |
dc.subject | Reed-sternberg cells | |
dc.subject | B-cells | |
dc.subject | Presenting features | |
dc.subject | Disease | |
dc.subject | Impact | |
dc.subject | Ebv | |
dc.subject | Infection | |
dc.subject | Lmp1 | |
dc.subject | Membrane-protein-1 | |
dc.subject.decs | Herpesvirus Humano 4 | |
dc.subject.decs | Enfermedad de Hodgkin | |
dc.subject.decs | Proteínas de la Membrana | |
dc.subject.decs | Doxorrubicina | |
dc.subject.decs | Ganglios Linfáticos | |
dc.subject.decs | Dacarbazina | |
dc.subject.decs | Formaldehído | |
dc.subject.decs | Radioterapia | |
dc.subject.decs | Vinblastina | |
dc.subject.decs | Quimioterapia | |
dc.subject.mesh | Hodgkin Disease | |
dc.subject.mesh | Herpesvirus 4, Human | |
dc.subject.mesh | Vinblastine | |
dc.subject.mesh | Bleomycin | |
dc.subject.mesh | Dacarbazine | |
dc.subject.mesh | Doxorubicin | |
dc.subject.mesh | Epstein-Barr Virus Infections | |
dc.subject.mesh | Antineoplastic Combined Chemotherapy Protocols | |
dc.subject.mesh | Lymphoma | |
dc.subject.mesh | Tomography, X-Ray Computed | |
dc.title | Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 13 | |
dc.wostype | Article |
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