Prognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma

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dc.contributor.authorSantisteban-Espejo, Antonio
dc.contributor.authorPerez-Requena, Jose
dc.contributor.authorAtienza-Cuevas, Lidia
dc.contributor.authorMoran-Sanchez, Julia
dc.contributor.authordel Carmen Fernandez-Valle, Maria
dc.contributor.authorBernal-Florindo, Irene
dc.contributor.authorRomero-Garcia, Raquel
dc.contributor.authorGarcia-Rojo, Marcial
dc.contributor.authoraffiliation[Santisteban-Espejo, Antonio] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Perez-Requena, Jose] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Atienza-Cuevas, Lidia] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Garcia-Rojo, Marcial] Puerta Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Santisteban-Espejo, Antonio] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Bernal-Florindo, Irene] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Romero-Garcia, Raquel] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Garcia-Rojo, Marcial] Prov Cadiz INiBICA, Inst Res & Innovat Biomed Sci, Cadiz 11009, Spain
dc.contributor.authoraffiliation[Santisteban-Espejo, Antonio] Univ Cadiz, Dept Med, Fac Med, Cadiz 11003, Spain
dc.contributor.authoraffiliation[Moran-Sanchez, Julia] Univ Cadiz, Dept Med, Fac Med, Cadiz 11003, Spain
dc.contributor.authoraffiliation[Moran-Sanchez, Julia] Puerta del Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz 11009, Spain
dc.contributor.authoraffiliation[del Carmen Fernandez-Valle, Maria] Puerta del Mar Univ Hosp, Dept Hematol & Hemotherapy, Cadiz 11009, Spain
dc.contributor.funderAndalusia Health System and with the EU FEDER ITI Grant for Cadiz Province
dc.date.accessioned2025-01-07T13:07:38Z
dc.date.available2025-01-07T13:07:38Z
dc.date.issued2021-12-01
dc.description.abstractThe prognostic impact of the presence of Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) is controversial. Previous studies reported heterogeneous results, rendering difficult the clinical validation of EBV as a prognostic biomarker in this lymphoma. The objective of this study was to evaluate the survival impact of the expression of EBV Latent-Membrane Protein 1 (EBV-LMP1) in tumoral Hodgkin-Reed-Sternberg (HRS) cells of primary diagnostic samples of cHL. Formalin-Fixed Paraffin-Embedded (FFPE) lymph node samples from 88 patients with cHL were analyzed. Patients were treated with the standard first-line chemotherapy (CT) with Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) followed by radiotherapy. The Kaplan-Meier method and the Cox proportional hazards model were used for carrying out the survival analysis. In order to investigate whether the influence of EBV was age-dependent, analyses were performed both for patients of all ages and for age-stratified subgroups. In bivariate analysis, the expression of EBV was associated with older age (p = 0.011), mixed cellularity subtype cHL (p
dc.identifier.doi10.3390/v13122523
dc.identifier.essn1999-4915
dc.identifier.pmid34960792
dc.identifier.unpaywallURLhttps://www.mdpi.com/1999-4915/13/12/2523/pdf?version=1639711053
dc.identifier.urihttps://hdl.handle.net/10668/25268
dc.identifier.wosID737465700001
dc.issue.number12
dc.journal.titleViruses-basel
dc.journal.titleabbreviationViruses-basel
dc.language.isoen
dc.organizationSAS - Hospital Universitario Puerta del Mar
dc.organizationSAS - Hospital Universitario Puerta del Mar
dc.organizationInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA)
dc.publisherMdpi
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectB-cell lymphomas
dc.subjectclassical Hodgkin lymphoma
dc.subjectEpstein-Barr virus
dc.subjectLatent-Membrane Protein 1
dc.subjectrisk-adjusted therapy
dc.subjectAge-defined subgroups
dc.subjectReed-sternberg cells
dc.subjectB-cells
dc.subjectPresenting features
dc.subjectDisease
dc.subjectImpact
dc.subjectEbv
dc.subjectInfection
dc.subjectLmp1
dc.subjectMembrane-protein-1
dc.titlePrognostic Role of the Expression of Latent-Membrane Protein 1 of Epstein-Barr Virus in Classical Hodgkin Lymphoma
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13
dc.wostypeArticle

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