Publication: The L162V polymorphism of the PPARA gene is associated with stage C of heart failure.
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Identifiers
Date
2009
Authors
Beaumont, Javier
Arias, Teresa
López, Begoña
Zalba, Guillermo
Belloqui, Oscar
García-Bolao, Ignacio
Barba, Joaquín
Teresa, Eduardo de
Díez, Javier
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
American Heart Association
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Abstract
In human heart failure (HF) peroxisome proliferator-activated receptor alpha (PPAR alpha) is downregulated and consequently, the expression of genes involved in fatty acid oxidation repressed. The L162V (rs1800206) is a functional polymorphism of the human PPAR alpha gene (PPARA). In the present study we have investigated whether this polymorphism is associated with the development of stage C of HF.
Description
Abstract 1921. Contents: Volume 120, Issue 18 Supplement; November 3, 2009 / Abstracts From Scientific Sessions 2009
MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-CH Group Donors::Acyl-CoA Dehydrogenases
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides::Polynucleotides::Oligonucleotides::Oligodeoxyribonucleotides::DNA Primers
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Heart Failure
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors::PPAR alpha
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Plasmids
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides::Polynucleotides::Oligonucleotides::Oligodeoxyribonucleotides::DNA Primers
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Heart Failure
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors::PPAR alpha
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Plasmids
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
DeCS Terms
CIE Terms
Keywords
Acil-CoA Deshidrogenasa, Cartilla de ADN, Insuficiencia Cardíaca, PPAR alfa, Humanos, Plásmidos, Polimorfismo Genético, ARN Mensajero
Citation
Beaumont, Javier; Arias, Teresa; Lopez, Begona; Zalba, Guillermo; Beloqui, Oscar; Garcia-Bolao, Ignacio; et al. The L162V polymorphism of the PPARA gene is associated with stage C of heart failure. Circulation. 2009;120(18 Suppl 2):S571