Effect of omega-3 fatty acids on hypoalbuminemia in acute heart failure patients with increased inflammatory activity
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2021-09-01
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Bonilla Palomas, Juan Luis
Gamez Lopez, Antonio Luis
Moreno Conde, Mirian
Lopez Ibanez, Maria Cristina
Moreno Villar, Maria Amparo
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Aran ediciones, s l
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Abstract
Introduction: inflammatory activity (IA) is a cause of hypoalbuminemia in patients with acute heart failure (AHF).Objectives: the main objective of this study was to evaluate whether an AI modulator treatment contributes to correcting albuminemia in this context.Methods: in this clinical trial 43 patients with AHF, hypoalbuminemia (serum albumin = 25 mg/l] were randomly assigned to receive omega-3 fatty acids (4 g daily) or placebo for 4 weeks. Albuminemia and CRP were reassessed at weeks 1 and 4. An analysis of variance for repeated measures was performed.Results: mean age was 75.6 +/- 8.8 years, 72.1 % were male, and the most frequent etiology was ischemic (46.5 %). The two groups were homogeneous in their baseline characteristics. A significant increase in albumin concentration was found at week 4 from baseline (p for the effect of time
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Heart failure, Hypoalbuminemia, Inflammatory activity, Omega-3 polyunsaturated fatty acids, Clinical trial, Polyunsaturated fatty-acids, Levels predict survival, Necrosis-factor-alpha, Serum-albumin, European-society, Protein, Activation, Receptors, Mortality, Diagnosis