Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.
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2016-11-18
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Erdreich-Epstein, Anat
Singh, Alok R
Joshi, Shweta
Vega, Francisco M
Guo, Pinzheng
Xu, Jingying
Groshen, Susan
Ye, Wei
Millard, Melissa
Campan, Mihaela
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Abstract
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αvβ3 was increased in high-risk metastatic (stage 4) NB compared with localized neuroblastomas. Herein, we show that integrin αvβ3 was expressed on 68% of microvessels in MYCN-amplified stage 3 neuroblastomas, but only on 34% (means) in MYCN-non-amplified tumors (p
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BRD4, PI3-kinase inhibitors, angiogenesis, integrin αvβ3, neuroblastoma