%0 Journal Article
%A Erdreich-Epstein, Anat
%A Singh, Alok R
%A Joshi, Shweta
%A Vega, Francisco M
%A Guo, Pinzheng
%A Xu, Jingying
%A Groshen, Susan
%A Ye, Wei
%A Millard, Melissa
%A Campan, Mihaela
%A Morales, Guillermo
%A Garlich, Joseph R
%A Laird, Peter W
%A Seeger, Robert C
%A Shimada, Hiroyuki
%A Durden, Donald L
%T Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.
%D 2016
%U https://hdl.handle.net/10668/25125
%X Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αvβ3 was increased in high-risk metastatic (stage 4) NB compared with localized neuroblastomas. Herein, we show that integrin αvβ3 was expressed on 68% of microvessels in MYCN-amplified stage 3 neuroblastomas, but only on 34% (means) in MYCN-non-amplified tumors (p
%K BRD4
%K PI3-kinase inhibitors
%K angiogenesis
%K integrin αvβ3
%K neuroblastoma
%~