Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.

Simple item page
dc.contributor.authorErdreich-Epstein, Anat
dc.contributor.authorSingh, Alok R
dc.contributor.authorJoshi, Shweta
dc.contributor.authorVega, Francisco M
dc.contributor.authorGuo, Pinzheng
dc.contributor.authorXu, Jingying
dc.contributor.authorGroshen, Susan
dc.contributor.authorYe, Wei
dc.contributor.authorMillard, Melissa
dc.contributor.authorCampan, Mihaela
dc.contributor.authorMorales, Guillermo
dc.contributor.authorGarlich, Joseph R
dc.contributor.authorLaird, Peter W
dc.contributor.authorSeeger, Robert C
dc.contributor.authorShimada, Hiroyuki
dc.contributor.authorDurden, Donald L
dc.date.accessioned2025-01-07T13:00:03Z
dc.date.available2025-01-07T13:00:03Z
dc.date.issued2016-11-18
dc.description.abstractNeuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αvβ3 was increased in high-risk metastatic (stage 4) NB compared with localized neuroblastomas. Herein, we show that integrin αvβ3 was expressed on 68% of microvessels in MYCN-amplified stage 3 neuroblastomas, but only on 34% (means) in MYCN-non-amplified tumors (p
dc.identifier.doi10.18632/oncotarget.13386
dc.identifier.essn1949-2553
dc.identifier.pmcPMC5581022
dc.identifier.pmid28881723
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5581022/pdf
dc.identifier.unpaywallURLhttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13386&path%5B%5D=42480
dc.identifier.urihttps://hdl.handle.net/10668/25125
dc.issue.number32
dc.journal.titleOncotarget
dc.journal.titleabbreviationOncotarget
dc.language.isoen
dc.organizationSAS - Hospital Universitario de Jerez de la Frontera
dc.organizationSAS - Hospital Universitario Virgen Macarena
dc.page.number52193-52210
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBRD4
dc.subjectPI3-kinase inhibitors
dc.subjectangiogenesis
dc.subjectintegrin αvβ3
dc.subjectneuroblastoma
dc.titleAssociation of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
PMC5581022.pdf
Size:
3.21 MB
Format:
Adobe Portable Document Format
Download

Collections

SAS - Hospital Universitario de Jerez de la Frontera
SAS - Hospital Universitario Virgen Macarena

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía