RT Journal Article
T1 Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.
A1 Erdreich-Epstein, Anat
A1 Singh, Alok R
A1 Joshi, Shweta
A1 Vega, Francisco M
A1 Guo, Pinzheng
A1 Xu, Jingying
A1 Groshen, Susan
A1 Ye, Wei
A1 Millard, Melissa
A1 Campan, Mihaela
A1 Morales, Guillermo
A1 Garlich, Joseph R
A1 Laird, Peter W
A1 Seeger, Robert C
A1 Shimada, Hiroyuki
A1 Durden, Donald L
K1 BRD4
K1 PI3-kinase inhibitors
K1 angiogenesis
K1 integrin αvβ3
K1 neuroblastoma
AB Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αvβ3 was increased in high-risk metastatic (stage 4) NB compared with localized neuroblastomas. Herein, we show that integrin αvβ3 was expressed on 68% of microvessels in MYCN-amplified stage 3 neuroblastomas, but only on 34% (means) in MYCN-non-amplified tumors (p
YR 2016
FD 2016-11-18
LK https://hdl.handle.net/10668/25125
UL https://hdl.handle.net/10668/25125
LA en
DS RISalud
RD Apr 4, 2025