Publication: Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways
Loading...
Identifiers
Date
2021-03-14
Authors
González-Domínguez, Raúl
González-Domínguez, Álvaro
Sayago, Ana
González-Sanz, Juan Diego
Lechuga-Sancho, Alfonso María
Fernández-Recamales, Ángeles
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Metrics
Export
Abstract
Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer's disease. This review article provides a comprehensive revision of the literature published on the use of mass spectrometry-based metabolomics platforms for approaching the central metabolome in Alzheimer's disease research, including direct mass spectrometry, gas chromatography-mass spectrometry, hydrophilic interaction liquid chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Overall, mounting evidence points to profound disturbances that affect a multitude of central metabolic pathways, such as the energy-related metabolism, the urea cycle, the homeostasis of amino acids, fatty acids and nucleotides, neurotransmission, and others.
Description
MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolome
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction::Synaptic Transmission
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Urea
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry
Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolome
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction::Synaptic Transmission
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Urea
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry
Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases
DeCS Terms
CIE Terms
Keywords
Central metabolites, Alzheimer’s disease, Mass spectrometry, Central metabolic pathways, Enfermedad de Alzheimer, Espectrometría de masas, Redes y vías metabólicas, Metabolómica, Homeostasis
Citation
González-Domínguez R, González-Domínguez Á, Sayago A, González-Sanz JD, Lechuga-Sancho AM, Fernández-Recamales Á. Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways. Biomedicines. 2021 Mar 14;9(3):298