RT Journal Article
T1 Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways
A1 González-Domínguez, Raúl
A1 González-Domínguez, Álvaro
A1 Sayago, Ana
A1 González-Sanz, Juan Diego
A1 Lechuga-Sancho, Alfonso María
A1 Fernández-Recamales, Ángeles
K1 Central metabolites
K1 Alzheimer’s disease
K1 Mass spectrometry
K1 Central metabolic pathways
K1 Enfermedad de Alzheimer
K1 Espectrometría de masas
K1 Redes y vías metabólicas
K1 Metabolómica
K1 Homeostasis
AB Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer's disease. This review article provides a comprehensive revision of the literature published on the use of mass spectrometry-based metabolomics platforms for approaching the central metabolome in Alzheimer's disease research, including direct mass spectrometry, gas chromatography-mass spectrometry, hydrophilic interaction liquid chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Overall, mounting evidence points to profound disturbances that affect a multitude of central metabolic pathways, such as the energy-related metabolism, the urea cycle, the homeostasis of amino acids, fatty acids and nucleotides, neurotransmission, and others.
PB MDPI
YR 2021
FD 2021-03-14
LK http://hdl.handle.net/10668/4595
UL http://hdl.handle.net/10668/4595
LA en
NO González-Domínguez R, González-Domínguez Á, Sayago A, González-Sanz JD, Lechuga-Sancho AM, Fernández-Recamales Á. Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways. Biomedicines. 2021 Mar 14;9(3):298
DS RISalud
RD May 13, 2025