TY - JOUR AU - González-Domínguez, Raúl AU - González-Domínguez, Álvaro AU - Sayago, Ana AU - González-Sanz, Juan Diego AU - Lechuga-Sancho, Alfonso María AU - Fernández-Recamales, Ángeles PY - 2021 DO - 10.3390/biomedicines9030298 UR - http://hdl.handle.net/10668/4595 T2 - Biomedicines AB - Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer's disease. This review article provides a... LA - en PB - MDPI KW - Central metabolites KW - Alzheimer’s disease KW - Mass spectrometry KW - Central metabolic pathways KW - Enfermedad de Alzheimer KW - Espectrometría de masas KW - Redes y vías metabólicas KW - Metabolómica KW - Homeostasis KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolome KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction::Synaptic Transmission KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Urea KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry KW - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases TI - Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways TY - review article ER -