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Title: | Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways |
Authors: | González-Domínguez, Raúl González-Domínguez, Álvaro Sayago, Ana González-Sanz, Juan Diego Lechuga-Sancho, Alfonso María Fernández-Recamales, Ángeles |
metadata.dc.contributor.authoraffiliation: | [González-Domínguez,R; Sayago,A; Fernández-Recamales,Á] AgriFood Laboratory, Faculty of Experimental Sciences, University of Huelva, Huelva, Spain. [González-Domínguez,R; Sayago,A; Fernández-Recamales,Á] International Campus of Excellence CeiA3, University of Huelva, Huelva, Spain. [González-Domínguez,Á; Lechuga-Sancho,AM] Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. [González-Sanz,JD] Department of Nursing, COIDESO Research Center, University of Huelva, Huelva, Spain. [Lechuga-Sancho,AM] Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, Cádiz, Spain [Lechuga-Sancho,AM] Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, Cádiz, Spain. |
Keywords: | Central metabolites;Alzheimer’s disease;Mass spectrometry;Central metabolic pathways;Enfermedad de Alzheimer;Espectrometría de masas;Redes y vías metabólicas;Metabolómica;Homeostasis |
metadata.dc.subject.mesh: | Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolome Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction::Synaptic Transmission Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Urea Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases |
Issue Date: | 14-Mar-2021 |
Publisher: | MDPI |
Citation: | González-Domínguez R, González-Domínguez Á, Sayago A, González-Sanz JD, Lechuga-Sancho AM, Fernández-Recamales Á. Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways. Biomedicines. 2021 Mar 14;9(3):298 |
Abstract: | Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer's disease. This review article provides a comprehensive revision of the literature published on the use of mass spectrometry-based metabolomics platforms for approaching the central metabolome in Alzheimer's disease research, including direct mass spectrometry, gas chromatography-mass spectrometry, hydrophilic interaction liquid chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Overall, mounting evidence points to profound disturbances that affect a multitude of central metabolic pathways, such as the energy-related metabolism, the urea cycle, the homeostasis of amino acids, fatty acids and nucleotides, neurotransmission, and others. |
URI: | http://hdl.handle.net/10668/4595 |
metadata.dc.relation.publisherversion: | https://www.mdpi.com/2227-9059/9/3/298 |
metadata.dc.identifier.doi: | 10.3390/biomedicines9030298 |
ISSN: | 2227-9059 (Online) |
Appears in Collections: | 01 - Artículos - INiBICA. Instituto de Investigación e Innovación Biomédica de Cádiz 01- Artículos - Hospital Puerta del Mar |
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File | Description | Size | Format | |
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GonzalezDominguez_MechanisticInsights.pdf | Revisión | 581,71 kB | Adobe PDF | View/Open |
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