Publication: MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.
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2017-01-16
Authors
Beaumont, Javier
López, Begoña
Ravassa, Susana
Hermida, Nerea
San José, Gorka
Gallego, Idoia
Valencia, Félix
Gómez-Doblas, Juan José
de Teresa, Eduardo
Díez, Javier
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Abstract
This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p
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MeSH Terms
Aged
Aortic Valve Stenosis
Biomarkers
Collagen
Comorbidity
Echocardiography
Female
Fibrosis
Gene Expression Regulation
Heart Failure
Heart Function Tests
Humans
Male
MicroRNAs
Myocardium
RNA Interference
Transcriptome
Aortic Valve Stenosis
Biomarkers
Collagen
Comorbidity
Echocardiography
Female
Fibrosis
Gene Expression Regulation
Heart Failure
Heart Function Tests
Humans
Male
MicroRNAs
Myocardium
RNA Interference
Transcriptome