RT Journal Article
T1 MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.
A1 Beaumont, Javier
A1 López, Begoña
A1 Ravassa, Susana
A1 Hermida, Nerea
A1 San José, Gorka
A1 Gallego, Idoia
A1 Valencia, Félix
A1 Gómez-Doblas, Juan José
A1 de Teresa, Eduardo
A1 Díez, Javier
A1 González, Arantxa
AB This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p 
YR 2017
FD 2017-01-16
LK http://hdl.handle.net/10668/10778
UL http://hdl.handle.net/10668/10778
LA en
DS RISalud
RD Apr 10, 2025