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MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.

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dc.contributor.authorBeaumont, Javier
dc.contributor.authorLópez, Begoña
dc.contributor.authorRavassa, Susana
dc.contributor.authorHermida, Nerea
dc.contributor.authorSan José, Gorka
dc.contributor.authorGallego, Idoia
dc.contributor.authorValencia, Félix
dc.contributor.authorGómez-Doblas, Juan José
dc.contributor.authorde Teresa, Eduardo
dc.contributor.authorDíez, Javier
dc.contributor.authorGonzález, Arantxa
dc.date.accessioned2023-01-25T09:43:01Z
dc.date.available2023-01-25T09:43:01Z
dc.date.issued2017-01-16
dc.description.abstractThis study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p 
dc.identifier.doi10.1038/srep40696
dc.identifier.essn2045-2322
dc.identifier.pmcPMC5238428
dc.identifier.pmid28091585
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238428/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/srep40696.pdf
dc.identifier.urihttp://hdl.handle.net/10668/10778
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.language.isoen
dc.organizationHospital Universitario Virgen de la Victoria
dc.page.number40696
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAged
dc.subject.meshAortic Valve Stenosis
dc.subject.meshBiomarkers
dc.subject.meshCollagen
dc.subject.meshComorbidity
dc.subject.meshEchocardiography
dc.subject.meshFemale
dc.subject.meshFibrosis
dc.subject.meshGene Expression Regulation
dc.subject.meshHeart Failure
dc.subject.meshHeart Function Tests
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMicroRNAs
dc.subject.meshMyocardium
dc.subject.meshRNA Interference
dc.subject.meshTranscriptome
dc.titleMicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number7
dspace.entity.typePublication

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