Publication: Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
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Identifiers
Date
2011-02-17
Authors
Domínguez-Sánchez, María S.
Sáez, Carmen
Japón, Miguel A.
Aguilera, Andrés
Luna, Rosa
Advisors
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Publisher
BioMed Central
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Abstract
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.
Description
MeSH Terms
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Nuclear Proteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Carrier Proteins::RNA-Binding Proteins::Ribonucleoproteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Cell Cycle Proteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Nuclear Proteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Carrier Proteins::RNA-Binding Proteins::Ribonucleoproteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Cell Cycle Proteins
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Keywords
Neoplasias de la Mama, Proteínas Nucleares, Ribonucleoproteínas, Proteínas de Unión al ARN, Proteínas de Ciclo Celular
Citation
Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011 Feb 17;11:77.