Publication: Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
| dc.contributor.author | Domínguez-Sánchez, María S. | |
| dc.contributor.author | Sáez, Carmen | |
| dc.contributor.author | Japón, Miguel A. | |
| dc.contributor.author | Aguilera, Andrés | |
| dc.contributor.author | Luna, Rosa | |
| dc.contributor.authoraffiliation | [Domínguez-Sánchez MS, Aguilera A, Luna R] Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain. [Sáez,C; Japón,MA]Instituto de Biomedicina de Sevilla (IBIS) and Department of Pathology, Hospital Universitario Virgen del Rocío/Universidad de Sevilla/CSIC. | es |
| dc.contributor.funder | This work was funded by research grants from the Spanish Ministry of Science and Innovation (BFU2007-28647-E, CSD2007-00015, PO7-CVI-02549 and ISCIII-RETIC-RD06/0020-FEDER) and the Junta de Andalucia (BIO-102). M.S. D-S was the recipient of a FPI predoctoral training grant from the Junta de Andalucía. | |
| dc.date.accessioned | 2012-01-27T12:07:07Z | |
| dc.date.available | 2012-01-27T12:07:07Z | |
| dc.date.issued | 2011-02-17 | |
| dc.description.abstract | One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples. | es |
| dc.description.version | Yes | es |
| dc.identifier.citation | Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011 Feb 17;11:77. | es |
| dc.identifier.doi | 10.1186/1471-2407-11-77 | |
| dc.identifier.essn | 1471-2407 | |
| dc.identifier.uri | http://hdl.handle.net/10668/287 | |
| dc.journal.title | BMC Cancer | |
| dc.language.iso | en | |
| dc.publisher | BioMed Central | es |
| dc.relation.publisherversion | http://www.biomedcentral.com/1471-2407/11/77 | es |
| dc.rights.accessRights | open access | |
| dc.subject | Neoplasias de la Mama | es |
| dc.subject | Proteínas Nucleares | es |
| dc.subject | Ribonucleoproteínas | es |
| dc.subject | Proteínas de Unión al ARN | es |
| dc.subject | Proteínas de Ciclo Celular | es |
| dc.subject.mesh | Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Nuclear Proteins | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Carrier Proteins::RNA-Binding Proteins::Ribonucleoproteins | es |
| dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Cell Cycle Proteins | es |
| dc.title | Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers | es |
| dc.type | research article | |
| dc.type.hasVersion | VoR | |
| dspace.entity.type | Publication |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Dominguez_Differentialexpression.pdf
- Size:
- 3.47 MB
- Format:
- Adobe Portable Document Format
- Description:
- Artículo publicado