RT Journal Article
T1 Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
A1 Domínguez-Sánchez, María S.
A1 Sáez, Carmen
A1 Japón, Miguel A.
A1 Aguilera, Andrés
A1 Luna, Rosa
K1 Neoplasias de la Mama
K1 Proteínas Nucleares
K1 Ribonucleoproteínas
K1 Proteínas de Unión al ARN
K1 Proteínas de Ciclo Celular
AB One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.
PB BioMed Central
YR 2011
FD 2011-02-17
LK http://hdl.handle.net/10668/287
UL http://hdl.handle.net/10668/287
LA en
NO Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011 Feb 17;11:77.
DS RISalud
RD Apr 9, 2025