%0 Journal Article
%A Domínguez-Sánchez, María S.
%A Sáez, Carmen
%A Japón, Miguel A.
%A Aguilera, Andrés
%A Luna, Rosa
%T Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
%D 2011
%U http://hdl.handle.net/10668/287
%X One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.
%K Neoplasias de la Mama
%K Proteínas Nucleares
%K Ribonucleoproteínas
%K Proteínas de Unión al ARN
%K Proteínas de Ciclo Celular
%~