Publication: Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting.
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Date
2018-04-25
Authors
Afram, Gabriel
Simón, Jose Antonio Pérez
Remberger, Mats
Caballero-Velázquez, Teresa
Martino, Rodrigo
Piñana, Jose Luis
Ringden, Olle
Esquirol, Albert
Lopez-Corral, Lucia
Garcia, Irene
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Abstract
Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p
Description
MeSH Terms
Adolescent
Adult
Aged
Child
Child, Preschool
Chronic Disease
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Infant
Male
Middle Aged
Retrospective Studies
Risk Factors
Transplantation Conditioning
Transplantation, Homologous
Young Adult
Adult
Aged
Child
Child, Preschool
Chronic Disease
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Infant
Male
Middle Aged
Retrospective Studies
Risk Factors
Transplantation Conditioning
Transplantation, Homologous
Young Adult
DeCS Terms
CIE Terms
Keywords
ATG, Graft-versus-host disease (GVHD), Risk factor