%0 Journal Article
%A Afram, Gabriel
%A Simón, Jose Antonio Pérez
%A Remberger, Mats
%A Caballero-Velázquez, Teresa
%A Martino, Rodrigo
%A Piñana, Jose Luis
%A Ringden, Olle
%A Esquirol, Albert
%A Lopez-Corral, Lucia
%A Garcia, Irene
%A López-Godino, Oriana
%A Sierra, Jordi
%A Caballero, Dolores
%A Ljungman, Per
%A Vazquez, Lourdes
%A Hägglund, Hans
%T Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting.
%D 2018
%U http://hdl.handle.net/10668/12395
%X Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p 
%K ATG
%K Graft-versus-host disease (GVHD)
%K Risk factor
%~