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Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting.

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dc.contributor.authorAfram, Gabriel
dc.contributor.authorSimón, Jose Antonio Pérez
dc.contributor.authorRemberger, Mats
dc.contributor.authorCaballero-Velázquez, Teresa
dc.contributor.authorMartino, Rodrigo
dc.contributor.authorPiñana, Jose Luis
dc.contributor.authorRingden, Olle
dc.contributor.authorEsquirol, Albert
dc.contributor.authorLopez-Corral, Lucia
dc.contributor.authorGarcia, Irene
dc.contributor.authorLópez-Godino, Oriana
dc.contributor.authorSierra, Jordi
dc.contributor.authorCaballero, Dolores
dc.contributor.authorLjungman, Per
dc.contributor.authorVazquez, Lourdes
dc.contributor.authorHägglund, Hans
dc.date.accessioned2023-01-25T10:07:28Z
dc.date.available2023-01-25T10:07:28Z
dc.date.issued2018-04-25
dc.description.abstractChronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p 
dc.identifier.doi10.1007/s12032-018-1127-2
dc.identifier.essn1559-131X
dc.identifier.pmcPMC5918523
dc.identifier.pmid29696461
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918523/pdf
dc.identifier.unpaywallURLhttps://link.springer.com/content/pdf/10.1007/s12032-018-1127-2.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12395
dc.issue.number6
dc.journal.titleMedical oncology (Northwood, London, England)
dc.journal.titleabbreviationMed Oncol
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number79
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectATG
dc.subjectGraft-versus-host disease (GVHD)
dc.subjectRisk factor
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshChronic Disease
dc.subject.meshFemale
dc.subject.meshGraft vs Host Disease
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Factors
dc.subject.meshTransplantation Conditioning
dc.subject.meshTransplantation, Homologous
dc.subject.meshYoung Adult
dc.titleReduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number35
dspace.entity.typePublication

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