RT Journal Article
T1 Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting.
A1 Afram, Gabriel
A1 Simón, Jose Antonio Pérez
A1 Remberger, Mats
A1 Caballero-Velázquez, Teresa
A1 Martino, Rodrigo
A1 Piñana, Jose Luis
A1 Ringden, Olle
A1 Esquirol, Albert
A1 Lopez-Corral, Lucia
A1 Garcia, Irene
A1 López-Godino, Oriana
A1 Sierra, Jordi
A1 Caballero, Dolores
A1 Ljungman, Per
A1 Vazquez, Lourdes
A1 Hägglund, Hans
K1 ATG
K1 Graft-versus-host disease (GVHD)
K1 Risk factor
AB Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p 
YR 2018
FD 2018-04-25
LK http://hdl.handle.net/10668/12395
UL http://hdl.handle.net/10668/12395
LA en
DS RISalud
RD Apr 5, 2025