Publication: Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.
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Identifiers
Date
2016-04-20
Authors
Garcia-Martinez, Lucrecia
Gracia-Ahulfinger, Irene
Machuca, Isabel
Cantisan, Sara
De La Fuente, Soraya
Natera, Clara
Perez-Nadales, Elena
Vidal, Elisa
Rivero, Antonio
Rodriguez-Lopez, Fernando
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
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Abstract
There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
Description
MeSH Terms
Drug utilization
Education, medical, continuing
Enterococcus faecalis
Gram-positive bacterial infections
Health policy
Hospitals, university
Humans
Linezolid
Non-randomized controlled trials as topic
Retrospective studies
Staphylococcus
Surveys and questionnaires
Tertiary care centers
Education, medical, continuing
Enterococcus faecalis
Gram-positive bacterial infections
Health policy
Hospitals, university
Humans
Linezolid
Non-randomized controlled trials as topic
Retrospective studies
Staphylococcus
Surveys and questionnaires
Tertiary care centers
DeCS Terms
Centros de atención terciaria
Educación médica continua
Estudios retrospectivos
Hospitales universitarios
Infecciones por bacterias grampositivas
Política de salud
Utilización de medicamentos
Educación médica continua
Estudios retrospectivos
Hospitales universitarios
Infecciones por bacterias grampositivas
Política de salud
Utilización de medicamentos
CIE Terms
Keywords
Anti-bacterial agents, Attitude of health personnel, Behavior therapy, Drug resistance, bacterial
Citation
García-Martínez L, Gracia-Ahulfinger I, Machuca I, Cantisán S, De La Fuente S, Natera C, et al. Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study. J Antimicrob Chemother. 2016 Sep;71(9):2606-11