%0 Journal Article
%A Garcia-Martinez, Lucrecia
%A Gracia-Ahulfinger, Irene
%A Machuca, Isabel
%A Cantisan, Sara
%A De La Fuente, Soraya
%A Natera, Clara
%A Perez-Nadales, Elena
%A Vidal, Elisa
%A Rivero, Antonio
%A Rodriguez-Lopez, Fernando
%A Del Prado, Jose Ramon
%A Torre-Cisneros, Julian
%T Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.
%D 2016
%U http://hdl.handle.net/10668/10140
%X There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P  A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
%K Anti-bacterial agents
%K Attitude of health personnel
%K Behavior therapy
%K Drug resistance, bacterial
%~