RT Journal Article
T1 Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.
A1 Garcia-Martinez, Lucrecia
A1 Gracia-Ahulfinger, Irene
A1 Machuca, Isabel
A1 Cantisan, Sara
A1 De La Fuente, Soraya
A1 Natera, Clara
A1 Perez-Nadales, Elena
A1 Vidal, Elisa
A1 Rivero, Antonio
A1 Rodriguez-Lopez, Fernando
A1 Del Prado, Jose Ramon
A1 Torre-Cisneros, Julian
K1 Anti-bacterial agents
K1 Attitude of health personnel
K1 Behavior therapy
K1 Drug resistance, bacterial
AB There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P  A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
PB Oxford University Press
YR 2016
FD 2016-04-20
LK http://hdl.handle.net/10668/10140
UL http://hdl.handle.net/10668/10140
LA en
NO García-Martínez L, Gracia-Ahulfinger I, Machuca I, Cantisán S, De La Fuente S, Natera C, et al. Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study. J Antimicrob Chemother. 2016 Sep;71(9):2606-11
DS RISalud
RD Apr 18, 2025