Publication: Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
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2021-12-27
Authors
Peinado, María Ángeles
Ovelleiro, David
Del Moral, María Luisa
Hernández, Raquel
Martínez-Lara, Esther
Siles, Eva
Pedrajas, José Rafael
García-Martín, María Luisa
Caro, Carlos
Peralta, Sebastián
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Abstract
Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value
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MeSH Terms
Animals
Blood-Brain Barrier
Brain Infarction
Endocytosis
Gene Ontology
Infarction, Middle Cerebral Artery
Magnetic Resonance Imaging
Male
Nanoparticles
Neuroglobin
Neurons
Neuroprotective Agents
Nitrosative Stress
Oxidative Stress
Principal Component Analysis
Proteomics
Rats, Wistar
Stroke
Survival Analysis
Thiobarbituric Acid Reactive Substances
Blood-Brain Barrier
Brain Infarction
Endocytosis
Gene Ontology
Infarction, Middle Cerebral Artery
Magnetic Resonance Imaging
Male
Nanoparticles
Neuroglobin
Neurons
Neuroprotective Agents
Nitrosative Stress
Oxidative Stress
Principal Component Analysis
Proteomics
Rats, Wistar
Stroke
Survival Analysis
Thiobarbituric Acid Reactive Substances
DeCS Terms
CIE Terms
Keywords
MCAO, hyaluronate nanoparticles, neuroglobin, neuroprotection, proteomics, stroke