RT Journal Article
T1 Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
A1 Peinado, María Ángeles
A1 Ovelleiro, David
A1 Del Moral, María Luisa
A1 Hernández, Raquel
A1 Martínez-Lara, Esther
A1 Siles, Eva
A1 Pedrajas, José Rafael
A1 García-Martín, María Luisa
A1 Caro, Carlos
A1 Peralta, Sebastián
A1 Morales, María Encarnación
A1 Ruiz, María Adolfina
A1 Blanco, Santos
K1 MCAO
K1 hyaluronate nanoparticles
K1 neuroglobin
K1 neuroprotection
K1 proteomics
K1 stroke
AB Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value
YR 2021
FD 2021-12-27
LK http://hdl.handle.net/10668/21127
UL http://hdl.handle.net/10668/21127
LA en
DS RISalud
RD Apr 7, 2025