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Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.

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dc.contributor.authorPeinado, María Ángeles
dc.contributor.authorOvelleiro, David
dc.contributor.authorDel Moral, María Luisa
dc.contributor.authorHernández, Raquel
dc.contributor.authorMartínez-Lara, Esther
dc.contributor.authorSiles, Eva
dc.contributor.authorPedrajas, José Rafael
dc.contributor.authorGarcía-Martín, María Luisa
dc.contributor.authorCaro, Carlos
dc.contributor.authorPeralta, Sebastián
dc.contributor.authorMorales, María Encarnación
dc.contributor.authorRuiz, María Adolfina
dc.contributor.authorBlanco, Santos
dc.date.accessioned2023-05-03T14:00:05Z
dc.date.available2023-05-03T14:00:05Z
dc.date.issued2021-12-27
dc.description.abstractExogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value
dc.identifier.doi10.3390/ijms23010247
dc.identifier.essn1422-0067
dc.identifier.pmcPMC8745106
dc.identifier.pmid35008673
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745106/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1422-0067/23/1/247/pdf?version=1641454198
dc.identifier.urihttp://hdl.handle.net/10668/21127
dc.issue.number1
dc.journal.titleInternational journal of molecular sciences
dc.journal.titleabbreviationInt J Mol Sci
dc.language.isoen
dc.organizationCentro Andaluz de Nanomedicina y Biotecnología-BIONAND
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMCAO
dc.subjecthyaluronate nanoparticles
dc.subjectneuroglobin
dc.subjectneuroprotection
dc.subjectproteomics
dc.subjectstroke
dc.subject.meshAnimals
dc.subject.meshBlood-Brain Barrier
dc.subject.meshBrain Infarction
dc.subject.meshEndocytosis
dc.subject.meshGene Ontology
dc.subject.meshInfarction, Middle Cerebral Artery
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshNanoparticles
dc.subject.meshNeuroglobin
dc.subject.meshNeurons
dc.subject.meshNeuroprotective Agents
dc.subject.meshNitrosative Stress
dc.subject.meshOxidative Stress
dc.subject.meshPrincipal Component Analysis
dc.subject.meshProteomics
dc.subject.meshRats, Wistar
dc.subject.meshStroke
dc.subject.meshSurvival Analysis
dc.subject.meshThiobarbituric Acid Reactive Substances
dc.titleBiological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number23
dspace.entity.typePublication

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