TY - JOUR AU - Peinado, María Ángeles AU - Ovelleiro, David AU - Del Moral, María Luisa AU - Hernández, Raquel AU - Martínez-Lara, Esther AU - Siles, Eva AU - Pedrajas, José Rafael AU - García-Martín, María Luisa AU - Caro, Carlos AU - Peralta, Sebastián AU - Morales, María Encarnación AU - Ruiz, María Adolfina AU - Blanco, Santos PY - 2021 DO - 10.3390/ijms23010247 UR - http://hdl.handle.net/10668/21127 T2 - International journal of molecular sciences AB - Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs... LA - en KW - MCAO KW - hyaluronate nanoparticles KW - neuroglobin KW - neuroprotection KW - proteomics KW - stroke KW - Animals KW - Blood-Brain Barrier KW - Brain Infarction KW - Endocytosis KW - Gene Ontology KW - Infarction, Middle Cerebral Artery KW - Magnetic Resonance Imaging KW - Male KW - Nanoparticles KW - Neuroglobin KW - Neurons KW - Neuroprotective Agents KW - Nitrosative Stress KW - Oxidative Stress KW - Principal Component Analysis KW - Proteomics KW - Rats, Wistar KW - Stroke KW - Survival Analysis KW - Thiobarbituric Acid Reactive Substances TI - Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases. TY - research article VL - 23 ER -