Publication: Genome-wide assessment of Parkinson's disease in a Southern Spanish population
No Thumbnail Available
Identifiers
Date
2016-09-01
Authors
Bandres-Ciga, Sara
Price, Timothy Ryan
Barrero, Francisco Javier
Escamilla-Sevilla, Francisco
Pelegrina, Javier
Arepalli, Sampath
Hernandez, Dena
Gutierrez, Blanca
Cervilla, Jorge
Rivera, Margarita
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier science inc
Metrics
Export
Abstract
Here, we set out to study the genetic architecture of Parkinson's disease (PD) through a Genome-Wide Association Study in a Southern Spanish population. About 240 PD cases and 192 controls were geno-typed on the NeuroX array. We estimated genetic variation associated with PD risk and age at onset (AAO). Risk profile analyses for PD and AAO were performed using a weighted genetic risk score. Total heritability was estimated by genome-wide complex trait analysis. Rare variants were screened with single-variant and burden tests. We also screened for variation in known PD genes. Finally, we explored runs of homozygosity and structural genomic variations. We replicate PD association (uncorrected p-value
Description
MeSH Terms
DeCS Terms
CIE Terms
Keywords
Parkinson's disease, Genetics, GWAS, Southern Spain, Risk loci, Genetic risk, Mutations, Association, Metaanalysis, Age, Identification, Variants, Complex, Region