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Genome-wide assessment of Parkinson's disease in a Southern Spanish population

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dc.contributor.authorBandres-Ciga, Sara
dc.contributor.authorPrice, Timothy Ryan
dc.contributor.authorBarrero, Francisco Javier
dc.contributor.authorEscamilla-Sevilla, Francisco
dc.contributor.authorPelegrina, Javier
dc.contributor.authorArepalli, Sampath
dc.contributor.authorHernandez, Dena
dc.contributor.authorGutierrez, Blanca
dc.contributor.authorCervilla, Jorge
dc.contributor.authorRivera, Margarita
dc.contributor.authorRivera, Alberto
dc.contributor.authorDing, Jing-hui
dc.contributor.authorVives, Francisco
dc.contributor.authorNalls, Michael
dc.contributor.authorSingleton, Andrew
dc.contributor.authorDuran, Raquel
dc.contributor.authoraffiliation[Bandres-Ciga, Sara] Univ Granada, Ctr Invest Biomed CIBM, Dept Physiol, Granada 18016, Spain
dc.contributor.authoraffiliation[Vives, Francisco] Univ Granada, Ctr Invest Biomed CIBM, Dept Physiol, Granada 18016, Spain
dc.contributor.authoraffiliation[Duran, Raquel] Univ Granada, Ctr Invest Biomed CIBM, Dept Physiol, Granada 18016, Spain
dc.contributor.authoraffiliation[Bandres-Ciga, Sara] Univ Granada, Ctr Invest Biomed CIBM, Inst Neurosci Federico Oloriz, Granada 18016, Spain
dc.contributor.authoraffiliation[Gutierrez, Blanca] Univ Granada, Ctr Invest Biomed CIBM, Inst Neurosci Federico Oloriz, Granada 18016, Spain
dc.contributor.authoraffiliation[Cervilla, Jorge] Univ Granada, Ctr Invest Biomed CIBM, Inst Neurosci Federico Oloriz, Granada 18016, Spain
dc.contributor.authoraffiliation[Rivera, Margarita] Univ Granada, Ctr Invest Biomed CIBM, Inst Neurosci Federico Oloriz, Granada 18016, Spain
dc.contributor.authoraffiliation[Vives, Francisco] Univ Granada, Ctr Invest Biomed CIBM, Inst Neurosci Federico Oloriz, Granada 18016, Spain
dc.contributor.authoraffiliation[Duran, Raquel] Univ Granada, Ctr Invest Biomed CIBM, Inst Neurosci Federico Oloriz, Granada 18016, Spain
dc.contributor.authoraffiliation[Price, Timothy Ryan] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Arepalli, Sampath] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Hernandez, Dena] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Rivera, Alberto] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Ding, Jing-hui] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Nalls, Michael] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Singleton, Andrew] NIA, Neurogenet Lab, NIH, Bethesda, MD USA
dc.contributor.authoraffiliation[Barrero, Francisco Javier] Univ Hosp San Cecilio, Movement Disorders Unit, Granada, Spain
dc.contributor.authoraffiliation[Pelegrina, Javier] Univ Hosp San Cecilio, Movement Disorders Unit, Granada, Spain
dc.contributor.authoraffiliation[Escamilla-Sevilla, Francisco] Univ Hosp Virgen Nieves, Inst Invest Biosanitaria IBS, Dept Neurol, Movement Disorders Unit, Granada, Spain
dc.contributor.authoraffiliation[Gutierrez, Blanca] Univ Granada, Ctr Invest Biomed CIBM, Dept Psychiat, Granada, Spain
dc.contributor.authoraffiliation[Cervilla, Jorge] Univ Granada, Ctr Invest Biomed CIBM, Dept Psychiat, Granada, Spain
dc.contributor.authoraffiliation[Rivera, Margarita] Univ Granada, Ctr Invest Biomed CIBM, Dept Psychiat, Granada, Spain
dc.contributor.authoraffiliation[Gutierrez, Blanca] Univ Granada, CIBER Salud Mental CIBERSAM, Granada, Spain
dc.contributor.authoraffiliation[Cervilla, Jorge] Univ Granada, CIBER Salud Mental CIBERSAM, Granada, Spain
dc.contributor.authoraffiliation[Rivera, Margarita] Univ Granada, CIBER Salud Mental CIBERSAM, Granada, Spain
dc.contributor.funderIntramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services
dc.contributor.funderJunta de Andalucia
dc.contributor.funderAndalusian Society of Neurology
dc.contributor.funderFPU fellowship
dc.contributor.funderSpanish Ministry of Education and Science
dc.contributor.funderNATIONAL INSTITUTE ON AGING
dc.date.accessioned2023-02-12T02:21:02Z
dc.date.available2023-02-12T02:21:02Z
dc.date.issued2016-09-01
dc.description.abstractHere, we set out to study the genetic architecture of Parkinson's disease (PD) through a Genome-Wide Association Study in a Southern Spanish population. About 240 PD cases and 192 controls were geno-typed on the NeuroX array. We estimated genetic variation associated with PD risk and age at onset (AAO). Risk profile analyses for PD and AAO were performed using a weighted genetic risk score. Total heritability was estimated by genome-wide complex trait analysis. Rare variants were screened with single-variant and burden tests. We also screened for variation in known PD genes. Finally, we explored runs of homozygosity and structural genomic variations. We replicate PD association (uncorrected p-value
dc.identifier.doi10.1016/j.neurobiolaging.2016.06.001
dc.identifier.essn1558-1497
dc.identifier.issn0197-4580
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc4976046?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/18845
dc.identifier.wosID381092900026
dc.journal.titleNeurobiology of aging
dc.journal.titleabbreviationNeurobiol. aging
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.publisherElsevier science inc
dc.rights.accessRightsopen access
dc.subjectParkinson's disease
dc.subjectGenetics
dc.subjectGWAS
dc.subjectSouthern Spain
dc.subjectRisk loci
dc.subjectGenetic risk
dc.subjectMutations
dc.subjectAssociation
dc.subjectMetaanalysis
dc.subjectAge
dc.subjectIdentification
dc.subjectVariants
dc.subjectComplex
dc.subjectRegion
dc.titleGenome-wide assessment of Parkinson's disease in a Southern Spanish population
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number45
dc.wostypeArticle
dspace.entity.typePublication

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