RT Journal Article
T1 Genome-wide assessment of Parkinson's disease in a Southern Spanish population
A1 Bandres-Ciga, Sara
A1 Price, Timothy Ryan
A1 Barrero, Francisco Javier
A1 Escamilla-Sevilla, Francisco
A1 Pelegrina, Javier
A1 Arepalli, Sampath
A1 Hernandez, Dena
A1 Gutierrez, Blanca
A1 Cervilla, Jorge
A1 Rivera, Margarita
A1 Rivera, Alberto
A1 Ding, Jing-hui
A1 Vives, Francisco
A1 Nalls, Michael
A1 Singleton, Andrew
A1 Duran, Raquel
K1 Parkinson's disease
K1 Genetics
K1 GWAS
K1 Southern Spain
K1 Risk loci
K1 Genetic risk
K1 Mutations
K1 Association
K1 Metaanalysis
K1 Age
K1 Identification
K1 Variants
K1 Complex
K1 Region
AB Here, we set out to study the genetic architecture of Parkinson's disease (PD) through a Genome-Wide Association Study in a Southern Spanish population. About 240 PD cases and 192 controls were geno-typed on the NeuroX array. We estimated genetic variation associated with PD risk and age at onset (AAO). Risk profile analyses for PD and AAO were performed using a weighted genetic risk score. Total heritability was estimated by genome-wide complex trait analysis. Rare variants were screened with single-variant and burden tests. We also screened for variation in known PD genes. Finally, we explored runs of homozygosity and structural genomic variations. We replicate PD association (uncorrected p-value
PB Elsevier science inc
SN 0197-4580
YR 2016
FD 2016-09-01
LK http://hdl.handle.net/10668/18845
UL http://hdl.handle.net/10668/18845
LA en
DS RISalud
RD Apr 7, 2025