%0 Journal Article
%A Bandres-Ciga, Sara
%A Price, Timothy Ryan
%A Barrero, Francisco Javier
%A Escamilla-Sevilla, Francisco
%A Pelegrina, Javier
%A Arepalli, Sampath
%A Hernandez, Dena
%A Gutierrez, Blanca
%A Cervilla, Jorge
%A Rivera, Margarita
%A Rivera, Alberto
%A Ding, Jing-hui
%A Vives, Francisco
%A Nalls, Michael
%A Singleton, Andrew
%A Duran, Raquel
%T Genome-wide assessment of Parkinson's disease in a Southern Spanish population
%D 2016
%@ 0197-4580
%U http://hdl.handle.net/10668/18845
%X Here, we set out to study the genetic architecture of Parkinson's disease (PD) through a Genome-Wide Association Study in a Southern Spanish population. About 240 PD cases and 192 controls were geno-typed on the NeuroX array. We estimated genetic variation associated with PD risk and age at onset (AAO). Risk profile analyses for PD and AAO were performed using a weighted genetic risk score. Total heritability was estimated by genome-wide complex trait analysis. Rare variants were screened with single-variant and burden tests. We also screened for variation in known PD genes. Finally, we explored runs of homozygosity and structural genomic variations. We replicate PD association (uncorrected p-value
%K Parkinson's disease
%K Genetics
%K GWAS
%K Southern Spain
%K Risk loci
%K Genetic risk
%K Mutations
%K Association
%K Metaanalysis
%K Age
%K Identification
%K Variants
%K Complex
%K Region
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