Publication: Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.
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Date
2018-08-24
Authors
Ruiz-de-León, María J
Jiménez-Sousa, María A
Moreno, Santiago
García, Marcial
Gutiérrez-Rivas, Mónica
León, Agathe
Montero-Alonso, Marta
González-García, Juan
Resino, Salvador
Rallón, Norma
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Abstract
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.
Description
MeSH Terms
Adult
Biomarkers
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Chemokine CCL2
Cross-Sectional Studies
Exosomes
Female
HIV Infections
HIV-1
Humans
Male
MicroRNAs
Middle Aged
Plasma
Biomarkers
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Chemokine CCL2
Cross-Sectional Studies
Exosomes
Female
HIV Infections
HIV-1
Humans
Male
MicroRNAs
Middle Aged
Plasma
DeCS Terms
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Keywords
Elite controllers, Exosomes, HIV-1, Immune activation, Soluble biomarkers, miRNAs