RT Journal Article
T1 Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.
A1 Ruiz-de-León, María J
A1 Jiménez-Sousa, María A
A1 Moreno, Santiago
A1 García, Marcial
A1 Gutiérrez-Rivas, Mónica
A1 León, Agathe
A1 Montero-Alonso, Marta
A1 González-García, Juan
A1 Resino, Salvador
A1 Rallón, Norma
A1 Benito, José M
A1 Vallejo, Alejandro
A1 ECRIS Network integrated in the Spanish AIDS Research Network, 
K1 Elite controllers
K1 Exosomes
K1 HIV-1
K1 Immune activation
K1 Soluble biomarkers
K1 miRNAs
AB Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.
YR 2018
FD 2018-08-24
LK http://hdl.handle.net/10668/12921
UL http://hdl.handle.net/10668/12921
LA en
DS RISalud
RD Apr 7, 2025