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Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.

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dc.contributor.authorRuiz-de-León, María J
dc.contributor.authorJiménez-Sousa, María A
dc.contributor.authorMoreno, Santiago
dc.contributor.authorGarcía, Marcial
dc.contributor.authorGutiérrez-Rivas, Mónica
dc.contributor.authorLeón, Agathe
dc.contributor.authorMontero-Alonso, Marta
dc.contributor.authorGonzález-García, Juan
dc.contributor.authorResino, Salvador
dc.contributor.authorRallón, Norma
dc.contributor.authorBenito, José M
dc.contributor.authorVallejo, Alejandro
dc.contributor.authorECRIS Network integrated in the Spanish AIDS Research Network
dc.date.accessioned2023-01-25T10:21:57Z
dc.date.available2023-01-25T10:21:57Z
dc.date.issued2018-08-24
dc.description.abstractExosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.
dc.identifier.doi10.1016/j.jmii.2018.07.007
dc.identifier.essn1995-9133
dc.identifier.pmid30193823
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.jmii.2018.07.007
dc.identifier.urihttp://hdl.handle.net/10668/12921
dc.issue.number4
dc.journal.titleJournal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
dc.journal.titleabbreviationJ Microbiol Immunol Infect
dc.language.isoen
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number667-671
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectElite controllers
dc.subjectExosomes
dc.subjectHIV-1
dc.subjectImmune activation
dc.subjectSoluble biomarkers
dc.subjectmiRNAs
dc.subject.meshAdult
dc.subject.meshBiomarkers
dc.subject.meshCD4 Lymphocyte Count
dc.subject.meshCD4-Positive T-Lymphocytes
dc.subject.meshChemokine CCL2
dc.subject.meshCross-Sectional Studies
dc.subject.meshExosomes
dc.subject.meshFemale
dc.subject.meshHIV Infections
dc.subject.meshHIV-1
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMicroRNAs
dc.subject.meshMiddle Aged
dc.subject.meshPlasma
dc.titleLower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number52
dspace.entity.typePublication

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