Publication: Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.
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Date
2018-04-26
Authors
Fernández-García, Laura
Fernandez-Cuenca, Felipe
Blasco, Lucía
López-Rojas, Rafael
Ambroa, Anton
Lopez, María
Pascual, Álvaro
Bou, Germán
Tomás, María
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Abstract
The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
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MeSH Terms
Acinetobacter Infections
Acinetobacter baumannii
Anti-Bacterial Agents
Chlorhexidine
Drug Resistance, Multiple, Bacterial
Drug Tolerance
Humans
Imipenem
Microbial Sensitivity Tests
Plasmids
Toxin-Antitoxin Systems
beta-Lactamases
Acinetobacter baumannii
Anti-Bacterial Agents
Chlorhexidine
Drug Resistance, Multiple, Bacterial
Drug Tolerance
Humans
Imipenem
Microbial Sensitivity Tests
Plasmids
Toxin-Antitoxin Systems
beta-Lactamases
DeCS Terms
CIE Terms
Keywords
Acinetobacter, chlorhexidine, imipenem, persistence, tolerance, toxin-antitoxin