%0 Journal Article
%A Fernández-García, Laura
%A Fernandez-Cuenca, Felipe
%A Blasco, Lucía
%A López-Rojas, Rafael
%A Ambroa, Anton
%A Lopez, María
%A Pascual, Álvaro
%A Bou, Germán
%A Tomás, María
%T Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.
%D 2018
%U http://hdl.handle.net/10668/12158
%X The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
%K Acinetobacter
%K chlorhexidine
%K imipenem
%K persistence
%K tolerance
%K toxin-antitoxin
%~