Publication:
Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.

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dc.contributor.authorFernández-García, Laura
dc.contributor.authorFernandez-Cuenca, Felipe
dc.contributor.authorBlasco, Lucía
dc.contributor.authorLópez-Rojas, Rafael
dc.contributor.authorAmbroa, Anton
dc.contributor.authorLopez, María
dc.contributor.authorPascual, Álvaro
dc.contributor.authorBou, Germán
dc.contributor.authorTomás, María
dc.date.accessioned2023-01-25T10:04:09Z
dc.date.available2023-01-25T10:04:09Z
dc.date.issued2018-04-26
dc.description.abstractThe molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
dc.identifier.doi10.1128/AAC.00250-18
dc.identifier.essn1098-6596
dc.identifier.pmcPMC5923160
dc.identifier.pmid29463538
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923160/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1128/aac.00250-18
dc.identifier.urihttp://hdl.handle.net/10668/12158
dc.issue.number5
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob Agents Chemother
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen Macarena
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAcinetobacter
dc.subjectchlorhexidine
dc.subjectimipenem
dc.subjectpersistence
dc.subjecttolerance
dc.subjecttoxin-antitoxin
dc.subject.meshAcinetobacter Infections
dc.subject.meshAcinetobacter baumannii
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshChlorhexidine
dc.subject.meshDrug Resistance, Multiple, Bacterial
dc.subject.meshDrug Tolerance
dc.subject.meshHumans
dc.subject.meshImipenem
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshPlasmids
dc.subject.meshToxin-Antitoxin Systems
dc.subject.meshbeta-Lactamases
dc.titleRelationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number62
dspace.entity.typePublication

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