RT Journal Article
T1 Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.
A1 Fernandez-Garcia, Laura
A1 Fernandez-Cuenca, Felipe
A1 Blasco, Lucia
A1 Lopez-Rojas, Rafael
A1 Ambroa, Anton
A1 Lopez, Maria
A1 Pascual, Alvaro
A1 Bou, German
A1 Tomas, Maria
K1 Acinetobacter
K1 chlorhexidine
K1 imipenem
K1 persistence
K1 tolerance
K1 toxin-antitoxin
AB The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
PB American Society for Microbiology
YR 2018
FD 2018-04-26
LK http://hdl.handle.net/10668/12158
UL http://hdl.handle.net/10668/12158
LA en
NO Fernández-García L, Fernandez-Cuenca F, Blasco L, López-Rojas R, Ambroa A, Lopez M, et al. Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00250-18.
DS RISalud
RD Aug 23, 2025