Publication: In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI.
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Date
2022-02-14
Authors
Lopez-Perez, David
Redruello-Romero, Anaïs
Garcia-Rubio, Jesus
Arana, Carlos
Garcia-Escudero, Luis A
Tamayo, Francisco
Salmeron, Javier
Galvez, Julio
Leon, Josefa
Carazo, Angel
Advisors
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Publisher
Frontiers Research Foundation
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Abstract
The paradigm of mast cells in type 2 diabetes is changing. Although they were first considered deleterious inflammatory cells, now they seem to be important players driving adipose tissue homeostasis. Here we have employed a flow cytometry-based approach for measuring the surface expression of 4 proteins (CD45, CD117, CD203c, and FcϵRI) on mast cells of omental (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 96 patients with morbid obesity. The cohort was split into three groups: non-T2D, pre-T2D, and T2D. Noteworthy, patients with T2D have a mild condition (HbA1c
Description
MeSH Terms
Adipose Tissue
Diabetes Mellitus, Type 2
Humans
Leukocyte Common Antigens
Mast Cells
Obesity, Morbid
Phosphoric Diester Hydrolases
Proto-Oncogene Proteins c-kit
Pyrophosphatases
Receptors, IgE
Diabetes Mellitus, Type 2
Humans
Leukocyte Common Antigens
Mast Cells
Obesity, Morbid
Phosphoric Diester Hydrolases
Proto-Oncogene Proteins c-kit
Pyrophosphatases
Receptors, IgE
DeCS Terms
Antígenos comunes de leucocito
Diabetes Mellitus tipo 2
Hidrolasas diéster fosfóricas
Humanos
Mastocitos
Obesidad mórbida
Pirofosfatasas
Proteínas Proto-oncogénicas c-kit
Receptores de IgE
Tejido adiposo
Diabetes Mellitus tipo 2
Hidrolasas diéster fosfóricas
Humanos
Mastocitos
Obesidad mórbida
Pirofosfatasas
Proteínas Proto-oncogénicas c-kit
Receptores de IgE
Tejido adiposo
CIE Terms
Keywords
adipose tissue, bariatric surgery, flow cytometry, mast cell, obesity, type 2 diabetes
Citation
Lopez-Perez D, Redruello-Romero A, Garcia-Rubio J, Arana C, Garcia-Escudero LA, Tamayo F, et al. In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI. Front Endocrinol (Lausanne). 2022 Mar 15;13:818388.