RT Journal Article
T1 In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI.
A1 Lopez-Perez, David
A1 Redruello-Romero, Anaïs
A1 Garcia-Rubio, Jesus
A1 Arana, Carlos
A1 Garcia-Escudero, Luis A
A1 Tamayo, Francisco
A1 Salmeron, Javier
A1 Galvez, Julio
A1 Leon, Josefa
A1 Carazo, Angel
K1 adipose tissue
K1 bariatric surgery
K1 flow cytometry
K1 mast cell
K1 obesity
K1 type 2 diabetes
AB The paradigm of mast cells in type 2 diabetes is changing. Although they were first considered deleterious inflammatory cells, now they seem to be important players driving adipose tissue homeostasis. Here we have employed a flow cytometry-based approach for measuring the surface expression of 4 proteins (CD45, CD117, CD203c, and FcϵRI) on mast cells of omental (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 96 patients with morbid obesity. The cohort was split into three groups: non-T2D, pre-T2D, and T2D. Noteworthy, patients with T2D have a mild condition (HbA1c
PB Frontiers Research Foundation
SN 1664-2392
YR 2022
FD 2022-02-14
LK http://hdl.handle.net/10668/20558
UL http://hdl.handle.net/10668/20558
LA en
NO Lopez-Perez D, Redruello-Romero A, Garcia-Rubio J, Arana C, Garcia-Escudero LA, Tamayo F, et al. In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI. Front Endocrinol (Lausanne). 2022 Mar 15;13:818388.
DS RISalud
RD Apr 5, 2025