Publication:
In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI.

Simple item page
dc.contributor.authorLopez-Perez, David
dc.contributor.authorRedruello-Romero, Anaïs
dc.contributor.authorGarcia-Rubio, Jesus
dc.contributor.authorArana, Carlos
dc.contributor.authorGarcia-Escudero, Luis A
dc.contributor.authorTamayo, Francisco
dc.contributor.authorSalmeron, Javier
dc.contributor.authorGalvez, Julio
dc.contributor.authorLeon, Josefa
dc.contributor.authorCarazo, Angel
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderConserjería de Salud y Familias, Junta de Andalucía
dc.contributor.funderInstituto de Salud Carlos III (ISCIII)
dc.contributor.funderConserjería de Salud y Familias, Junta de Andalucía is a department of the regional government of Andalucía (Spain)
dc.date.accessioned2023-05-03T13:39:51Z
dc.date.available2023-05-03T13:39:51Z
dc.date.issued2022-02-14
dc.description.abstractThe paradigm of mast cells in type 2 diabetes is changing. Although they were first considered deleterious inflammatory cells, now they seem to be important players driving adipose tissue homeostasis. Here we have employed a flow cytometry-based approach for measuring the surface expression of 4 proteins (CD45, CD117, CD203c, and FcϵRI) on mast cells of omental (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 96 patients with morbid obesity. The cohort was split into three groups: non-T2D, pre-T2D, and T2D. Noteworthy, patients with T2D have a mild condition (HbA1c
dc.description.versionSi
dc.identifier.citationLopez-Perez D, Redruello-Romero A, Garcia-Rubio J, Arana C, Garcia-Escudero LA, Tamayo F, et al. In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI. Front Endocrinol (Lausanne). 2022 Mar 15;13:818388.
dc.identifier.doi10.3389/fendo.2022.818388
dc.identifier.issn1664-2392
dc.identifier.pmcPMC8965342
dc.identifier.pmid35370964
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965342/pdf
dc.identifier.unpaywallURLhttps://www.frontiersin.org/articles/10.3389/fendo.2022.818388/pdf
dc.identifier.urihttp://hdl.handle.net/10668/20558
dc.journal.titleFrontiers in endocrinology
dc.journal.titleabbreviationFront Endocrinol (Lausanne)
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number14
dc.provenanceRealizada la curación de contenido 20/08/2024
dc.publisherFrontiers Research Foundation
dc.pubmedtypeJournal Article
dc.relation.projectIDPI15/01361
dc.relation.projectIDPI18/01947
dc.relation.projectIDPIN-0235-2019
dc.relation.publisherversionhttps://doi.org/10.3389/fendo.2022.818388
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectadipose tissue
dc.subjectbariatric surgery
dc.subjectflow cytometry
dc.subjectmast cell
dc.subjectobesity
dc.subjecttype 2 diabetes
dc.subject.decsAntígenos comunes de leucocito
dc.subject.decsDiabetes Mellitus tipo 2
dc.subject.decsHidrolasas diéster fosfóricas
dc.subject.decsHumanos
dc.subject.decsMastocitos
dc.subject.decsObesidad mórbida
dc.subject.decsPirofosfatasas
dc.subject.decsProteínas Proto-oncogénicas c-kit
dc.subject.decsReceptores de IgE
dc.subject.decsTejido adiposo
dc.subject.meshAdipose Tissue
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshHumans
dc.subject.meshLeukocyte Common Antigens
dc.subject.meshMast Cells
dc.subject.meshObesity, Morbid
dc.subject.meshPhosphoric Diester Hydrolases
dc.subject.meshProto-Oncogene Proteins c-kit
dc.subject.meshPyrophosphatases
dc.subject.meshReceptors, IgE
dc.titleIn Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and FcϵRI.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
PMC8965342.pdf
Size:
4.4 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Lopez_InObese_MaterialSuplementario.docx
Size:
703.01 KB
Format:
Microsoft Word XML
Download

Collections

Instituto de Investigación Biosanitaria de Granada (ibsGRANADA)
SAS - Hospital Universitario San Cecilio

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía