Publication: Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp M-207 Associated with the Deep-Sea Coral Lophelia pertusa
No Thumbnail Available
Identifiers
Date
2017-05-01
Authors
Brana, Alfredo F.
Sarmiento-Vizcaino, Aida
Osset, Miguel
Perez-Victoria, Ignacio
Martin, Jesus
de Pedro, Nuria
de la Cruz, Mercedes
Diaz, Caridad
Vicente, Francisca
Reyes, Fernando
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Mdpi
Metrics
Export
Abstract
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Aviles Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.
Description
MeSH Terms
DeCS Terms
CIE Terms
Keywords
lobophorins, spirotetronate antibiotic, Streptomyces, antitumor, Cantabrian Sea-derived actinobacteria, Spirotetronate antibiotics, Metabolites