RT Journal Article
T1 Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp M-207 Associated with the Deep-Sea Coral Lophelia pertusa
A1 Brana, Alfredo F.
A1 Sarmiento-Vizcaino, Aida
A1 Osset, Miguel
A1 Perez-Victoria, Ignacio
A1 Martin, Jesus
A1 de Pedro, Nuria
A1 de la Cruz, Mercedes
A1 Diaz, Caridad
A1 Vicente, Francisca
A1 Reyes, Fernando
A1 Garcia, Luis A.
A1 Blanco, Gloria
K1 lobophorins
K1 spirotetronate antibiotic
K1 Streptomyces
K1 antitumor
K1 Cantabrian Sea-derived actinobacteria
K1 Spirotetronate antibiotics
K1 Metabolites
AB The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Aviles Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.
PB Mdpi
YR 2017
FD 2017-05-01
LK http://hdl.handle.net/10668/19298
UL http://hdl.handle.net/10668/19298
LA en
DS RISalud
RD Apr 5, 2025