%0 Journal Article
%A Brana, Alfredo F.
%A Sarmiento-Vizcaino, Aida
%A Osset, Miguel
%A Perez-Victoria, Ignacio
%A Martin, Jesus
%A de Pedro, Nuria
%A de la Cruz, Mercedes
%A Diaz, Caridad
%A Vicente, Francisca
%A Reyes, Fernando
%A Garcia, Luis A.
%A Blanco, Gloria
%T Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp M-207 Associated with the Deep-Sea Coral Lophelia pertusa
%D 2017
%U http://hdl.handle.net/10668/19298
%X The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Aviles Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.
%K lobophorins
%K spirotetronate antibiotic
%K Streptomyces
%K antitumor
%K Cantabrian Sea-derived actinobacteria
%K Spirotetronate antibiotics
%K Metabolites
%~